Liujundanshen Granules On Blood Stasis Phlegm And Blood Stasis Type Of Research On The Effects Of Vascular Endothelial Function In Patients With Hypertension

ObjectiveBy observing Liujundanshen granules (the granules of Liujundanshen decoction) on deficiency of phlegm and blood stasis type of clinical symptoms and vascular endothelial function in patients with hypertension and the effect of further verify its treating deficiency of phlegm and blood stasis type hypertension’s clinical curative effect, and discusses six gentleman danshen granules for damage of endothelial function is improved, in order to make clear the mechanism of the treatment of primary hypertension, provides the certain clinical basis for the new drug research and development of traditional Chinese medicine.MethodsAfter screening,108cases of hypertension patients with deficiency of phlegm and blood stasis type were included.56cases were randomly divided into treatment group and control group in52cases. The control group given basic treatment of western medicine (nifedipine retard-20tablet or maleic acid enalaprilat or betaloc, blood fat was abnormal with atorvastatin calcium), treatment group on the basis of the western medicine treatment with Liujundanshen granules. Respectively before and after treatment for3months,6months after treatment in patients with symptoms score points, the determination of the blood pressure, blood lipid, colour to exceed and carotid artery and brachial artery flow mediated dilation (FMD) examination of blood vessels. Finally the data statistical analysis, to draw conclusions.Results1.3months after treatment compared before and after the two groups of data shows that:the treatment group patients in the clinical symptom scores, systolic blood pressure levels, carotid artery IMT (except the right internal carotid artery IMT) and plaque quantity, brachial artery diastolic rates than before treatment significantly improved (P<0.05), the diastolic blood pressure, blood fat, right internal carotid artery IMT and treatment has no obvious differences (P>0.05); Control group in clinical symptom scores, systolic pressure, diastolic blood pressure, blood lipid, number of carotid IMT and plaque, brachial artery diastolic rates was not the obviously improved (P>0.05). Contrast between the two groups showed:treatment group in the clinical symptom scores, systolic blood pressure, left and right common carotid artery bifurcation IMT, left internal carotid artery IMT, brachial artery diastolic rates compared with control group improved significantly (P <0.05), while in diastolic blood pressure, blood lipid, left and right common carotid artery IMT, number of right internal carotid artery IMT and carotid plaques and the control group no significant differences (P>0.05).2Contrast before and after treatment for6months after the two sets of data show that two groups of patients in clinical symptom scores, systolic blood pressure, TC (cholesterol), carotid IMT, brachial artery diastolic rates than before treatment were significantly improved (P<0.05), while in diastolic blood pressure, TG (triglyceride), HDL (high density lipoprotein), and no significant difference (P>0.05) before treatment, the treatment group of the quantity of carotid plaques, LDL (low-density lipoprotein) level before the treatment also significantly improved (P<0.05), while the control group improvement is not obvious (P>0.05). Contrast between the two groups showed: treatment group in the clinical symptom scores, systolic pressure, diastolic blood pressure, LDL (low-density lipoprotein), carotid IMT and plaque number, brachial artery diastolic rate than the control group improved significantly (P<0.05), while in the TC (cholesterol), TG (triglyceride), HDL (high density lipoprotein) has no obvious difference between two groups (P>0.05).Conclusion1. Liujundanshen granules can effectively improve the deficiency of phlegm and blood stasis type of clinical symptoms of patients with high blood pressure.2. Liujundanshen granules have synergy antihypertensive effect for deficiency of phlegm and blood stasis type hypertension patients. 3.Liujundanshen granules have synergy lipid-lowering effect for deficiency of phlegm and blood stasis type hypertension patients.4. Liujundanshen granules can effectively improve the deficiency of phlegm and blood stasis type of high blood pressure in patients with atherosclerosis.5. Liujundanshen granules can effectively improve the deficiency of phlegm and blood stasis type endothelial diastolic function in patients with hypertension.