The Clinic Investigation About The Effect Of Shen-zao Yangxintang On The Left Ventricular Remodeling Of Acute Myocardial Infarction Who Had Treated By Percutaneous Coronary Intervention, And Were Belong To Qi Stagnation And Blood Stasis In The Traditional

BackgroundAcute Myocardial Infarction(AMI) are the one of the most serious and the highest mortality rate in Cardiovascular Disease(CVD). Under the extensive used the Thrombosis and Interventional techniques, the mortality rate of AMI had descended to10%in acute phase. But the higher morbidity in the advanced, such as Chronic Heart Failure and Arrhythmia, had heightened.This phenomenon was involved in Left Ventricular Remodel ing (LVR). LVR after AMI was defined as complex alterations in the left ventricular architecture and function involving both the infarct zone, which is involve the infarct expansion in the early6weeks and the global ventricular dilatation after6weeks, would seriously damaged the left ventricular function and increased mortality rate. Recently, interest has developed in limiting LVR, with the objective of improving ventricular function and clinical outcome. AMI was considered in the " thoracic obstruction""angina pectoris" in TCM. Many domestic doctors made a lot of research involving clinical and experimental study which focused on Etiology、Pathogenesis and Treatment, except the LVR after PCI. Shen-zao Yangxintang which is based on TCM fundamental theory and combined modern medicine is a recipe made by professor Zeng-ming to treat AMI, its function involves benefiting Qi for activating blood circulation. In this study, we will validate its clinical effect, and discuss its mechanism,, to improve the overall quality of life, and reduce the economic burdenPurpose Primarily evaluate the effect of Shen-zao Yangxintang to LVR after PCI who are belong to Qi deficiency and blood stasis type in AMI and discuss its possible mechanism.MethodsThis research uses the method of random comparison.60cases of Qi deficiency and blood stasis type in AMI in hospital are divided into two groups by random. A group is received the Western Medicine standard curing set, the another is received standard curing set and Shen-zao Yangxintang in6weeks. Compare the UCG results after6weeks with the PCI24h, such as LVEF、LVEDD、IVS、WMSI、CRP. Record the clinical symptoms and the life qualityResults1. The two groups before treatment, there was no statistically significant difference (P>0.05), had the comparability. The clinical symptoms in two groups had different degrees of improvement. The total effective rate was80.00%in treatment group,46.67%in control group, there was statistically significant difference (P<0.05).2. Between the Cardiac function and the left ventricular morphology, there was no statistically significant difference (P>0.05) in comparison in groups, and there was statistically significant difference (P<0.05) in comparison between groups.3. In the inflammatory markers, there was no statistically significant difference (P>0.05) in comparison in groups, and there was statistically significant difference (P>0.05) in comparison between groups.4. During the period of observation, there was not found the adverse reactions related to the treatment.Conclusion1. The Shen-zao Yangxintang united the conventional Western Medicine Treatment, had remarkable improved the clinical syndrome, such as Chest pain, Dyspnea, Palpitations, Malaise, had the clinical practicality.2. The clinical syndrome of the early LVR after AMI patient, in turn, was Chest pain, Dyspnea, Palpitations, Malaise, Anorexia, Spontaneous perspiration, Insomnia, who had the same syndrome with the AMI.3. The Shen-zao Yangxintang united the conventional Western Medicine Treatment, had remarkable reduced the patients’ CRP who was Qi deficiency and blood stasis type in AMI after PCI, presented that this function would worked by reduce inflammatory reaction.4. The Shen-zao Yangxintang united the conventional Western Medicine Treatment, had remarkable reduced the patients LVEDD、IVS and improved the Cardiac function, who was Qi deficiency and blood stasis type in AMI after PCI.5.In the process, there was not found the adverse reactions, nor the toxic and side effect, and it had the effected treatment. The Shen-zao Yangxintang is to popularized to the clinical.