| Objective: Overweight/obesity sarcopenia,defined as overweight/obesity associated with decreased muscle mass and strength,has been previously reported to be associated with cardiovascular disease in cross-sectional studies.However,little is known about the role of overweight/obesity sarcopenia in predicting left ventricular diastolic function and left ventricular remodeling.The purpose of this article was to evaluate the relationship between overweight/obesity combined with sarcopenia in patients with type 2 diabetes mellitus and left ventricular diastolic function and left ventricular remodeling?.Methods: A retrospective study was conducted on 496 patients(291 males and 205 females)with type 2 diabetes admitted to the department of endocrinology of the first affiliated hospital of fujian medical university from June 2008 to October 2018,who were matched by age and gender.The SMI and overweight/obesity defined by body mass index(BMI)and body mass index(BMI)were calculated by whole-body dual-core energy X-ray absorption.the patients were divided into four groups: normal group,only the sarcopenia group,only the overweight/obesity group,and the overweight/obesity combined with the sarcopenia group.Early diastolic mitral orifice velocity(E),mean early diastolic mitral annulus velocity(E),left ventricular mass index(LVMI),and R ventricular wall thickness(RWT)were calculated by cardiac ultrasonography.Left ventricular diastolic function was assessed by E/ E and mean E,and left ventricular remodeling was assessed by left ventricular mass(LVMI)and relative ventricular wall thickness(RWT)with standardized body surface area.QTc interval is the value after the influence of QT interval corrected heart rate(RR)by Bazett formula,namely QTc = QT/?RRResults: 1.The normal group,less muscle disease group,overweight/obesity group,overweight/obesity group and less muscle disorder in patients with type 2 diabetes in the frequency of subclinical left ventricular diastolic dysfunction was 49.2%,55.6%,60.5%,66.9%,appears the frequency of the left ventricular remodeling was 29.0%,22.6%,30.6%,41.9%,type 2 diabetes in subclinical left ventricular diastolic dysfunction and left ventricular remodeling the rising trend,the frequency as the grouping of less muscle disease in obesity group is the highest2.In the multivariate linear regression model,after adjustment for systolic blood pressure,diastolic blood pressure,low density,total cholesterol,high density,glycosylated hemoglobin,e GFR,smoking,alcohol consumption,and medication history,heart rate was positively correlated with sarcopenia and overweight/obesity(= 4.63,p<0.05;= 4.13,p<0.05);CO and SV were only positively correlated with overweight/obesity(= 0.378,p<0.05).= 6.443 p<0.05);Both insulin resistance index and CRP were positively correlated with overweight/obesity sarcopenia(?= 0.312,p<0.05?? = 0.294,p < 0.05)3.In logistic regression analysis,after adjusting for systolic blood pressure,diastolic blood pressure,high-density lipoprotein,e GFR,Hb A1 c,smoking history,drinking history and medication history,the risk of left ventricular diastolic dysfunction in overweight/obese patients with myositis was 2.172 times higher than that in normal patients(OR=2.172,95%CI=1.174-4.021,P=0.014).The risk of left ventricular remodeling was 2.047 times higher in the overweight/obese patients with sarcopenia than in the normal patients(OR=2.047,95%ci =1.095-3.828,P=0.025).4.Overweight/obesity combined with sarcopenia did not increase the prevalence of cardiac insufficiency and QT,and there was no significant difference in systolic function between the groups.Conclusion: Current data suggest that overweight/obesity associated with sarcopenia in type 2 diabetes is associated with left ventricular diastolic dysfunction and left ventricular remodeling.Overweight/obesity combined with sarcopenia may be used to determine cardiovascular events in patients with type 2 diabetes. |
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