Clinical Study On Facial Seborrheic Dermatitis By Two Solstices Pill Decoction Plus Tacrolimus Ointment

ObjectiveSeborrheic dermatitis (SD) lines occur in the scalp, face, neck, chest, back and other rich parts of the sebaceous glands, it is a chronic inflammatory skin diseases because of excessive sebum secretion. Severe cases with swelling, erosion, yellow water flow based on greasylupus, and may even appear systemic erythroderma. It not only affects the appearance. More importantly, the patients consciously itching, severely hampered the daily life. It is easy to diagnose in clinical, but whether it is traditional Chinese medical or Western medical, When using one single treatment, most of the time is still not effectively control the recurrence. How to reduce the recurrence rate has been the difficulty of treatment. Thus, the subject according to TCM theory combined with modern medical research, application old TCM professor Xuan Guowei’s clinical experience side-"Two solstices pill decoction" joint modern pharmaceutical research-Tacrolimus ointment for the treatment of facial seborrheic dermatitis. To investigate the changes of the integrative approach to the recurrence rate. In order to provide a new ideas for the treatment of disease in clinical.MethodsPatients with facial seborrheic dermatitis from June2013to March2014whom seek for treatment in Guangdong Provincial Hospital, were devided into treatment group and control group. Treatment group were52cases, and the control group have52cases. All patients need to be checked blood, liver function, renal function, autoimmune, immune and blood transfusion before treatment. All patients with negative results were use of0.03%tacrolimus ointment, twice a day. When skin lesions subsided (general two weeks),2-3times per week to maintain. Using a total of4weeks. Treatment group was given by the Two solstices pill decoction, once a day, blunt with150ml warm water. A course of one week, a total of4courses. The control group was given by particles placebo, once a day, blunt with150ml warm water. A course of one week, a total of4courses. After four weeks to determine the efficacy. Cured patients in two groups were follow-up a month, and determine the rate of clinical relapse. Truthfully recorded adverse reactions during treatment.Results1. Comparison of the results of general information:A total of116cases were collected, depigmentation10cases,3cases were lost because of own use of hormone creams,1case unfinished observed because of work. There are4cases off in control group because of the poor treatment effect. Two cases were lost with unexplained. There were1case exit the experimental observation in each group owing to adverse reactions. Completed a total of104cases of clinical observation. Each group in Gender, age, symptom score before treatment, the difference was not statistically significant (P>0.05).2. Comparison of clinical efficacy:After a month of treatment, the observations showed:the treatment group in cure, effective rate were higher than the control group (The treatment group cure rate63.46%, total efficiency98.08%; The control group:cure rate53.85%, total efficiency96.15%. P>0.05). Invalid rate in treatment group is lower than control group.(Invalid rate in treatment group1.92%; Invalid rate in control group3.85%, P>0.05)3. Adverse reactions recorded:There were1case exit the experimental observation in each group owing to adverse reactions, part of skin associated with flushing and itching, after1week discontinuation symptoms gradually disappear, the remaining patients were not found after treatment of the skin irritation and allergic reactions.ConclusionThere were114Patients with facial seborrheic dermatitis join in in the clinical observation(Treatment group were52cases, the control group were52cases), The treatment group cure rate63.46%, total efficiency98.08%; The control group:cure rate53.85%, total efficiency96.15%. Treatment effect is quite, but in terms of long-term efficacy, the treatment group significantly better than the control group. The results show that:Two solstices pill decoction associated with Tacrolimus ointment for the treatment of facial seborrheic dermatitis. Its therapeutic effect is certainly, significantly reduced the recurrence rate of the disease, For clinical solving the recurrence problem provides a new idea.