| ObjectiveObserve the clinical efficacy of topical pain one blood stasis type of moderate pain, and provide an objective basis for the solution gas line treatment of stasis pain; make cancer pain in patients with safer, more economical, effective and well-tolerated analgesic adjuvant drugs; enrich the contents of three ladder analgesic therapy; while also extends the theory of Traditional Chinese Medicinal treatment of cancer pain connotationMethodsMethods randomized controlled,70met the inclusion criteria patients were divided into treatment group (35cases) and control group (35cases) One treatment group were pain spreads in local pain points3h, qd. The control group cloth Gui hydrochloride tablets30mg, tid. There are two sets of cloth flunarizine given intramuscular injection0.1g outbreak pain. One week after the end of treatment were compared before and after treatment NRS scores, pain relief, pain outbreak situation, KPS score, adverse reactions and safety.ResultsThe study enrolled a total of70cases of patients, in order successively, using random number table to be randomly divided into two groups, the treatment group and the control group of35cases. Two cases during the study excluded cases in which the treatment group1patients, because the first day of sticking stickers medicine at the blisters appear, accompanied by intense itching and rashes, allergies judged sticking tape, topical medications to be deactivated immediately, in this case patients recorded as an adverse event, and not included in the efficacy analysis. Control group1patients, because patients in the medication process simultaneously observe the lesions cryoablation, consider this technique may reduce the pain, the impact assessment of efficacy, not included in the efficacy analysis. Therefore,34patients in the control group were included in the statistical analysis of34cases treated. The study included68patients, excluding the two cases.1. The total efficiency from two comparative (CR+PR+MR):31cases (91.18%) of the total effective rate of two treatment groups, a control group of30patients (88.24%); overall efficiency of the two groups showed no statistical significance, P=0.395. However, the bar graph can be seen in treatment group CR, the ratio of PR group than the control group2. NRS scores:Before taking dressing (d0), the first day after treatment (dl) to seventh (d7) NRS values were compared. After statistical analysis, d0-d7treatment group and the control group had no significant difference (P>0.05). But seen through the chart NRS decrease treatment group than the control group3. compare the number of outbreaks of pain:the treatment group (0.48±0.633) times the control group (0.07±0.26) times the number of occurrences of pain treatment group broke out less during treatment control group, statistical analysis, statistical differences significance P=0.046(P<0.05).4. KPS scores:the treatment group and the control group before and after treatment quality of life scores were not statistically different (P>0.05).5. adverse reactions:the treatment group2patients, the rate was5.9%six cases in the control group, the rate was17.6%, higher incidence of treatment group, the statistical analysis, the difference was statistically significant, P=0.032(P<0.05). The incidence of adverse reactions in treatment group was significantly lower than the control group.6. security baking, the two groups had no abnormal changes during treatment ConelusionFor one local application stasis pain of moderate cancer pain is effective and can effectively relieve pain in patients, does not affect the quality of life of cancer pain; and apply one continuous pain one week with still higher than its analgesic effect well maintained. One topical pain without systemic side effects, and simple, is the treatment of cancer pain safe, economical and effective means of treatment. To some extent can be greatly improved because the large amount of side effects caused by opioids... |
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