Clinical Study Of Topical Ke Tong San In Relieving Moderate Cancer Pain

Objective: To study whether the Ketongsan can relieve the moderate cancer pain,and the effect of ketongsan combined with opioids in the use of synergistic anti-cancer pain,and provide practical clinical evidence for the ketongsan relief of cancer pain.Methods: Fifty-seven patients were divided into two groups(experimental group,control group)with randomized single-blind method.Experimental group: apply ketongsan combined with oral oxycodone hydrochloride sustained-release tablets,and apply the ketongsan to the place where the pain is most obvious,twice a day,each lasting two hours.Each person takes oral oxycodone hydrochloride sustained-release tablets each day,12 hours 1 times.Control group: Oral oxycodone hydrochloride sustained-release tablets,use the same as the experimental group.7 days for a course of treatment,continuous observation of 2 courses.Results: 1.After the end of this experimen,the total effective rate of the experimental group was 86% and the control group was 62%.It showed that the experimental group analgesic effect was significantly better than the control group.2.Both groups of NRS scores were descended after the treatment,and there was significant difference between the experimental group and the control group,which indicated that the two groups' situation of the pain was improved obviously,and the improvement of the pain in the experimental group was better than that in the control group.3.Both groups of NRS scores were ascended after the treatment and were statistically significant(P <0.01).And there was significant difference between the experimental group and the control group and were statistically significant(P <0.01).It indicates that the experimental group of drygs and the control group of drugs have improvedthe quality of life of patients,and the effect of the experimental group of drugs on improving the quality of the patients' life is better than the control group of drugs.4.There were significant differences between the experimental group and the control group in the amount of oxycodone hydrochloride used,the time of onset of analgesia,the duration of maintenance and the number of bursts of pain.Compared with the control group,experimental group use oxycodone hydrochloride sustained-release tablets with less dose,but faster on function,longer on analgesic maintenance time,and less frequent bursts of pain5.Adverse reaction analysis: The incidence of nausea,vomiting,and constipation in the experimental group was less than that in the control group.6.Safety index analysis: In the course of treatment,only one case of adverse reactions in the experimental group(skin allergies in 1 case).Two groups of patients with blood,liver function,renal function,heart rate,blood pressure,breathing,pulse are in the normal range,indicating that the two groups of drugs are safe.Conclusions:In summary,the use of "ke tong san" on the treatment of moderate cancer pain has some certain clinical value,so it is worth further study.