Pain Block Elimination Cream Sex Body Pain Medicine For Cancer Clinical Research

Objective To evaluate the efficacy and safety of Tongkuaixiao Ointment(TKXO) combining with opioid analgesics in the treatment of Moderate-to-Severe somatic cancer pain.Methods In a prospective,randomized,placebo-controlled,double-blind clinical trial,124patients with Moderate-to-Severe somatic cancer pain were randomly divided into the TKXO group(Treatment group,N=63)and the placebo group(Control group,N=61),who were externally treated with Tongkuaixiao Ointment or the placebo and took opioid analgesics orally at the same time.The treatment was administered for5days.Results The NRS decreased obviously after5days’treatment in both two groups(TKXO group:6.44±1.43VS3.22±2.17,Placebo group:6.20±1.45VS3.48±2.34),but the difference between these two groups wasn’t statistically significant(P>0.05).The onset time of the two groups was3.16±2.18VS3.72±2.43(P>0.05),the duration was24.42±25.53VS12.02±11.25(P<0.05). Morphine dose of the first day of the two groups was38.97±41.43VS60.44±50.46(P<0.05),total dose was167.02±143.87VS216.96±192.16(P>0.05).The grade in impact of pain measurement decreased after5days’treatment(TKXO group:46.97±12.85VS24.06±16.75, Placebo group:47.48±11.67VS26.05±16.99), the difference between these two groups wasn’t statistically significant(P>0.05). The overall improvement rates of the two groups were95.24%VS93.44%, the difference between these two groups wasn’t statistically significant (P>0.05).No obvious adverse effects were found in the TKXO group.Conclusion It was demonstrated that Tongkuaixiao Ointment combining with opioid analgesics is effective and safe in the treatment of Moderate-to-Severe somatic cancer pain.