Clinical Research On Comorbidity Conditions Of Children With Cerebral Palsy

ObjectiveAfter data collection, clinical analysis, statistical analysis of comorbidity conditions of children with CP, this study aims to:Find out the common types of comorbidity conditions of CP and their incidence. Analysis the correlation between the number of comorbidity conditions and the risk factors, type of CP, degree, age, gender, TCM type of CP. Analysis the correlation between the common types of comorbidity conditions and the risk factors, type of CP, degree, age, gender, TCM type of CP.MethodsRefer to the medical records of children with CP who admit to the Nanhai affilited maternity and children’s hospital of Guangzhou university of tranditional Chinese medicine during December2008to December2013. Pick up all the first time records of the children who fit all the conditions, and with the help of pediatrician who have clinical experience, collect all the data, including risk factors, age. gender, type of cerebral palsy, GMFcs classification, TCM types of CP, examination results, types of comorbidity conditions, number of comorbidity conditions. After all the diagnosis and examination results be double confirmed, all the data will be entry to the computer by use the Epidata3.1, after data collation, use SPSS13.0for statistical analysisResults1. The survey included444children with cerebral palsy. There are442cases have comorbidity conditions (99.5%of the total). Different GMFcs classification have significant discrepancy on the incidence of comorbidity conditions (P<0.01).2. The number of comorbidity conditions is3.04+1.45,392children with CP have two or more comorbidity conditions (88.2%of the total). Different age, type of CP, GMFcs classification have significant discrepancy on the number of comorbidity conditions (P<0.05).3. The common types of comorbidity conditions and their influencing factors as follows:(1) Associated with mental retardation’s incidence was92.3%, most of them were very severe mental retardation(40.44%of the total). Different age, type of CP, GMFcs classification had discrepancy on mental retardation’s incidence (P<0.05).(2) Associated with peri ventricular leukomalacia’s incidence was32.8%, Different age, type of CP, GMFcs classification, risk factors had discrepancy on periventricular leukomalacia’s incidence (P<0.05).(3) Associated with cerebral dysplasia(except corpus callosum hypoplasia, White matter of brain dysplasia)’s incidence was32.1%, Different age, clinical type, GMFcs classification and risk factors had discrepancy on cerebral dysplasia’s incidence(P<0.05).(4) Associated with microcephaly’s incidence was26.0%, Different gender, age, GMFcs classification had discrepancy on microcephaly’s incidence (P<0.05).(5) Associated with visual impairment’s incidence was12.4%, most of them were strabismus (61.82%), Different clinical types had discrepancy on the incidence (P<0.01).(6) Associated with hearing impairment’s incidence was11.8%, most of them were both ears barriers dominant (96.15%). Different age, clinical type, GMFcs classification and risk factors had discrepancy on the incidence(P <0.05).(7) Associated with softening of the brain(except periventricular leukomalacia)’s incidence was11.5%. Different age, clinical type, GMFcs classification, risk factors had no discrepancy on the incidence(P>0.05)(8) Associated with malnutrition’s incidence was32.1%, most of them were moderate malnutrition (73.91%), Different GMFcs classification had discrepancy on the incidence (P<0.05).(9) Associated with epilepsy’s incidence was9.5%, Different GMFcs classification had discrepancy on the incidence (P<0.05).(10) Associated with corpus callosum hypoplasia’s incidence was7.7%. Different types of clinical had discrepancy on the incidence (P<0.05). 4. In addition, children with cerebral palsy often have a series of weak spleen and stomach symptoms, such as poor appetite, salivation, poor swallowing function, tongue out, constipation, irritability and sweat a lot.Gonelusion1. Comorbidity conditions of Children with CP were common and prone:the incidence was99.5%. And the less severe gross motor dysfunction were, the low incidence of comorbidity conditions were.2. Comorbidity conditions of Children with CP had different kinds:with two or more comorbidity conditions were88.2%of the total. And the younger, the less severe gross motor dysfunction were, the more species the comorbidity conditions were. In addition, Spastic CP group’s number of comorbidity conditions was higher than ataxia CP group, mixed type CP group’s number of comorbidity conditions was higher than dyskinetic CP group and ataxia CP group.3.The common types of comorbidity conditions(according to incidence of comorbidity conditions as follows):mental retardation, periventricular leukomalacia, cerebral hypoplasia(except corpus callosum hypoplasia, White matter of brain dysplasia), microcephaly, visual impairment, hearing impairment, cerebral softening(except periventricular leukomalacia), malnutrition, seizures, corpus callosum hypoplasia. In addition, children with cerebral palsy often have a series of weak spleen and stomach symptoms.4. Different comorbidity condition have different influencing factors, as follows:Different age, type of CP, GMFcs classification had discrepancy on mental retardation’s incidence. Different age, type of CP, GMFcs classification and risk factor had discrepancy on periventricular leukomalacia(except corpus callosum hypoplasia, White matter of brain dysplasia), cerebral hypoplasia,hearing impairment’s incidence. Different age, gender, GMFcs classification and risk factor had discrepancy on microcephaly’s incidence. Different type of CP had discrepancy on visual impairment and visual impairment’s incidence. Different GMFcs classification had discrepancy on malnutrition, seizures’s incidence. But each factor for each a type of comorbidity condition affect inconsistent.