The Research Of The Long-term Efficacy Of The Treatment"Regulatng The Mutual Interaction Between The Spleen And The Heart" On Patients With Coronary Heart Disease After Percutaneous Coronary Intervention

BackgroundIt is generally acknowledged that CHD (coronary heart disease) is a common disease which affects our health seriously. For this reason, various kinds of techniques and medications have been found to solve this tough problem and PCI (percutaneous coronary intervention) is, to a great extent, one of the major approaches concerning revascularization. Although the benefits with PCI for patients who suffer ACS (acute coronary syndrome) are immediate and considerable, the complications, however, such as restenosis and thrombogenesis, are inevitable. In order to tackle this challenge, Pr. Deng Tietao, one of the most well-known and honored veteran doctors of TCM (traditional Chinese medicine), initially applied the theory of the "Correlation of Five Viscera" to the treatment and secondary prevention of CHD. According to his doctrine in TCM, the core mechanism of CHD is the pathological interaction between the spleen and the heart, with the graduate accumulation of phlegm and blood stasis within the body. Therefore, a corresponding formula, whose main function is to regulate the interaction of the spleen and the heart, was invented. To explore the validity and efficacy of this theory, a series of clinical trials and experiments have been taken. The observation of lto3years’therapy with this formula, eventually proves its definite relief of symptoms, such as chest pain and weakness in patients after PCI, though the exact mechanisms remain unknown. Based on the previous research, this study is set to seek for the possible long-term curative effects of this treatment on patients with CHD after PCI.ObjectiveThe objective of the research is to evaluate the long-term efficacy of the treatment, regulating the mutual interaction between the spleen and the heart, on patients with CHD after PCI, in terms of cardiac death, myocardial infarction, revascularization, all-cause mortality and admission rate, cardiac function, symptom relief and TCM symptom score.MethodsThe research was a retrospective cohort study, following the640participants, who had anticipated the project " clinical trials for comprehensive interventions of TCM therapy on patients with CHD after revascularization" between April2008and August2009, from12hospitals in China.314cases of the total were distributed to the exposure group, while the other324formed the controlled one. Telephone follow-up was the main survey method, with outpatient meetings, e-mails as the supplemental ways. The medication compliances and the outcome events, such as cardiac death, myocardial infarction, revascularization, all-cause mortality and admission rate, cardiac function, symptom relief were attached to the most importance during the study.Results570patients were successfully followed.70cases dropped out due to the loss of follow-up or withdrew in response to patient demands.10were confirmed death.43needed revascularization during the past5years. The rehospitalization rate, the incidence of ischemic events, the improvement of cardiac function and the frequency, degree and duration of angina, as well as the total TCM symptom scores were seen much better among the exposure group than that of the placebo one{P<0.05). While the mortality rate, the occurrence rate of myocardial infarction and revascularization cases showed no statistical differences in the research between the2groups(P>0.05).ConclusionThe treatment, moderating the mutual interaction between the spleen and the heart, has positive effects on patients with CHD after PCI, in terms of rehospitalization rate, the incidence of ischemic events and the frequency, degree and duration of angina, as well as the total TCM symptom scores.