Thyroid Function Test And Influencing Factors Of Newborns

ObjectiveTo explore the thyroid function test and influencing factors of newborns. Subjects and MethodsOne hundred and fifty newborns whose mothers were diagnosed with thyroid dysfunction during pregnancy were involved as subjects in our hospital. T3, T4, FT3, FT4, TSH and Anti-TG were determined3d after birth. Finally18newborns with thyroid dysfunction were defined as abnormal group.22cases of normal newborns from remained132cases were defined as control group. The thyroid functions of all newborns were determined3d,2w,4w,8w,16w after birth. The clinical data and thyroid function were compared between two groups. In addition, the relationship between gestational age and thyroid function were analyzed.ResultsThe respiratory rate and heart rate in the abnormal group was lower than the control group. The difference was statistically significant (P<0.05). The TSH level in the abnormal group was significantly higher than the control group3d after birth. Then, the TSH levels decreased at2w but were still higher than the control group. The TSH levels at4w、8w and16w showed no statistically significant difference (P>0.05). The FT4level was significantly lower than the control group at3d. Then, the FT4level increased gradually at2w. The differences of FT4levels were not obvious at2w,4w,8w and16w between two groups (P>0.05). The T3, T4, FT3and Anti-TG levels between the abnormal group and the control group showed no significant difference (P>0.05). The FT43d after birth was positively correlated with gestational age (r=0.443, P=0.000); The TSH3d after birth was negatively correlated with gestational age (r=-0.597, P=0.000). T3, T4, FT3and Anti-TG showed no correlation with gestational age (P>0.05).Conelusion1. For pregnancy with the history of thyroid dysfunction or thyroid dysfunction during pregnancy, newborns should be closely monitored to ensure their physical and intellectual development.2For pregnancy with the history of thyroid dysfunction or thyroid dysfunction during pregnancy, newborns low heart rate and respiratory rate is caused by abnormal thyroid function should be paid attention to, in order to evaluate thyroid function status in time.3. Maternal thyroid dysfunction can cause newborn thyroid dysfunction, while FT4and TSH is the key indicator of early detection.4. For SGA the HPA axis development is not sound, the secretion of thyroid hormone level is unstable, it is important for SGA follow-up observation...