The Relational Study Between Serum Sodium Concentration And Plasma Concentration Of N-terminal Pro-brain Natriuretic Peptide And Interleukin-17in Patients With Congestive Heart Failure

Objective：To investigate the alleosis of plasma concentration of N-terminal (NT) pro-brainnatriuretic peptide (proBNP) and Interleukin-17(IL-17) by mensurating the indices ofIL-17and NT-proBNP with chronic heart failure． To study the variability ofbefore-mentioned indeces between different serum sodium level groups and the correlationbetween serum sodium and before-mentioned indeces.We also investigated the effect ofIL-17on myocardial fibrosis in this model. Our study demon-strates the contribution ofIL-17to myocardial fibrosis，in isoproterenol-induced HF. Interventions can be carried outas soon as possible from the cytokine,thereby delaying the occurrence and development ofheart failure.Methods：To evaluate the relationship involving serum sodium concentration and plasmaconcentration of NT-proBNP and IL-17, we identified70patients with congestive heartfailure in department of cardiology of Liaocheng Pepole’s Hospital from January,2012toDecember,2012. According to NYHA classification, they were reassigned to2subgroups:NYHAⅢgroup (32patients) and NYHA Ⅳ group (38patients). According to serumsodium level, they were reassigned to2subgroups: hyponatremia group (31patients) andnormal serum sodium group (39patients).35cases of normal heart function wereidentified as the control group. Baseline data were collated for all selected patients. TheNT-proBNP and IL-17level of all selected were detected and compared according tobefore-mentioned groups using statistical analysis and chart forms. Results：①Serum NT-proBNP and IL-17concentration were increased as the NYHA class ofheart failure increased，Normal heart function with NYHA Ⅲ group of patients：NT-proBNP（420±256vs7780±6393P<0．001）、IL-17(3.53±2.05vs8.65±3.05P<0．001)；NYHA Ⅲ and NYHAⅣ group of patients:NT-proBNP(7780±6393vs13704±10945P<0.01)、IL-17(8.65±3.05vs21.1±10.6P<0.001).②After excluding the influence of heartfunction， Serum NT-proBNP and IL-17level in patients with hyponatremia wassignificantly higher than that in patients with normal serum sodium concentration：NT-proBNP (14958±9691vs8107±5720P<0．01)、 IL-17(19.23±12.46vs9.9±6.2P<0．001)：③Serum sodium level was negative correlated with NT-proBNP and IL-17(r=一0.345，P＜0.01；r=0.369P<0.01)．Conclusion:1.With the NYHA classification increased, the serum NT-proBNP and IL-17concentration in patients wit demonstrate h chronic heart failure increased, regardless ofthe serum sodium level．It demonstrate that NT-proBNP and IL-17both played animportant role in the development of heart failure. So they could be used to assess the stateof disease.The brain natriuretic peptide is a reliable index to estimate the degree andprognosis in patients with heart failure which has been used widely.The experimentalresults show that the levels of Interleukin-17and brain natriuretic peptide level in parallelelevated，which descript that the interleukin-17can also be used to assess the degree andprognosis of heart failure and serum IL-17levels can be used as the judgment conditionindex in patients with congestive heart failure one of the effective index.2. Serum NT-proBNP and IL-17level in the hyponatremia group were significantlyhigher than that in the normal serum sodium group．That is to say, NT-proBNP and IL-17had negative correlation with serum sodium level.The study means that IL-17may play animportant role in the progress of heart failure during myocardial Remodeling.Significance:The result of this topic will help cellular signal transduction pathways aspects,Furtherelaborated from the cell-mediated immunity in the pathogenesis of heart failure. Interven-tions can be carried out as soon as possible from the cytokine,Thereby delaying theoccurrence and development of heart failure,To develop a new theoretical perspective forthe treatment of heart failure and provide a new theoretical basis.