Association Of The MiRNA-146a Polymorphism With Hepatocellular Cacinoma Risk:A Meta-analysis

Objective Previous studies have claimed the association of miRNA-146a rs2910164 polymorphism with the increased risk of hepatocellular cacinoma,but results from the published data were controversial.The aim of our present Meta-analysis was to estimate the overall association between miRNA-146a rs2910164 polymorphism and the risk of HCC.Methods Case-control studies with sufficient data evaluating the association between miRNA-146a rs2910164 polymorphism and HCC susceptibility were systematically identified inPubMed,Embase,Web of Science,China National Knowledge Infrastructure(CNKI)and Chinese Biomedical Literature Database(CBM)databases as of January 30,2017.Results A total of 18 case-control studies involving 5657 cases and 6680 healthy controls were collected for this meta-analysis.The pooled odds ratio(OR)with its 95%confidence interval(CI)was calculated to assess the genetic association betweenmiRNA-146a rs2910164 polymorphism and the risk of hepatocellular cacinoma.In this study,no enough proof was found to prove the association in any genetic model(C versus G:OR =0.96,95%CI=0.88-1.06;GC versus GG:OR ?0.98,95%CI =0.88-1.09;CC versus GG:OR =0.90,95%Cl = 0.74-1.09;GC/CC versus GG:OR = 0.95,95%CI=0.82-1.10;CC versus GC/GG:OR = 0.95,95%CI= 0.84-1.07).Conclusion Our results suggest that there is no sufficient evidence to support the association between rs2910164 polymorphism and hepatocellular cacinoma risk.Studies with larger sample size across diverse populations and subgroup analyses are necessary in the future.