The Association Between Two Common Polymorphisms(MiR146A RS2910164 And MiR-196A2 RS11614913) And Susceptibility To Gastric Cancer:a Meta-Analysis

Objective:To investigate the association between two single nucleotide polymorphisms (SNPs) in microRNAs (miR-146a rs2910164 and miR-196a2 rs11614913) and susceptibility to GC.Methods:We conducted a search of case-control studies in PubMed, Wiley Online Library, and the CNKI database. We used Stata/SE software 12.0 to analyze the data.Results:Eight case-control studies for rs2910164 and seven case-control studies for rs11614913 were identified and included in this meta-analysis. Our results showed that the only significant association between the miR-146a rs2910164 polymorphism and susceptibility to gastric cancer was found in the heterozygous model (OR=0.884,95% CI: 0.795-0.983, Ph=0.326, P＝0.022). Similarly, when stratified by ethnicity, there was an obvious correlation in the heterozygous model (OR=0.734, 95% CI:0.542-0.993, Ph=0.441, P=0.045) in European but not in Asian. For miR-196a2, this meta-analysis suggested that neither the allele frequency nor the genotype distribution of the polymorphism was associated with GC risk in the five genetic models. Similarly, the subgroup analysis by ethnicity showed no association with susceptibility to GC.Conclusion:Our studies suggested that the miR-146a rs2910164 polymorphism might marginally contribute to a decreased risk of gastric cancer, especially in European, whereas the miR-196a2 rs11614913 polymorphism might not be associated with susceptibility to GC.