Effect Of Glimepiride On Vascular Patency Rate After Vascular Anastomosis

Object:Glimepiride is a common clinical medication, but as the third generation sulfonylurea dr ug itself has the anticoagulant and antithrombotic effect. The aim of this study was desig ned to investigate the effects of glimepiride patency rate of vascular anastomosis, and w iden the application range of vascular anastomosis anticoagulant drug selection.Patients and methods:Healthy male SD rats, of common carotid artery and external jugular vein anastomosis, surgery were randomly divided into experimental group and control group, with12rats in each group, the body weight of200-250g. The experimental group was given intragas tric administration of glimepiride daily0.1mg/100g, control group for the same dose of water by gavage.5weeks after the examination of vascular recanalization, the anastomo tic distal vascular pathology inspection, at the same time, through the common carotid a rtery blood coagulation APTT/PT/TXB2index value. According to the judgment of the patency of the naked eye, anastomotic distal medial thickness and APTT/PT/TXB2inde x value, the two groups were compared to determine glimepiride to improve the patency rate of the role of vascular anastomosis.Results:1.Look to the naked eye recanalizationThe patency rate:the patency rate:experiment group:12, unobstructed8,the patency rat e was66.7%. Control group was12, unobstructed3, patency rate was25%.2.The anastomotic distal vascular in film thicknessBecause after the operation flow and pressure vein anastomosis was significantly increa sed compared with that before, leading to vascular layer thickening, vein arterialization, after5weeks in vascular patency group of film thickness is not unobstructed group of v ascular medial thickness was significantly thicker. Patency group film thickness maxim um and minimum values were:53.420um,34.036um. Obstructed group film thickness, maximum and minimum values were:there is statistically significant difference betwee n28.038um,15.533um,(p<0.05).3.5weeks after two groups of PT detection respectively.Glimepiride gavage group PT time compared to a control group without significantly pr olonged, there was no significant difference between the two groups (PT p>0.05):refer s to the extrinsic coagulation pathway of coagulation factor is not at all in the blood, and the external factor (TF) ginseng and hemostasis. This process is from the tissue factor e xposure to blood and start, process to the factor X is activated. Clinical on the prothrom bin time (PT) were measured to reflect the extrinsic pathway of blood coagulation status. The glimepiride group and control group, operation operation factors of thrombosis, tw o groups did not differ. Not disturbing factors of glimepiride on thrombosis through the extrinsic coagulation pathway.4.5weeks after the two groups were tested for APPT. Glimepiride gavage group APPT is longer than that in control group, a significant differ ence between the two groups (p<0.05) APTT extension is based on the endogenous for coagulation pathway factor (VIII, IX, X i) the impact of the implementation. Through the experiment we can draw, glimepiride i s affected by the intrinsic coagulation pathway, to achieve the prevention of thrombosis.5.5weeks after two groups of TXB2detection respectively. Glimepiride irrigation measuring the concentration of TXB2was significantly lower in gastric blood group than in the control group, showed significant difference between th e two groups (P<0.05) Thromboxane (thromboxane, TXA2) is a kind of prostaglandin in, by platelet productio n, with blood Plate cohesion and vasoconstriction, contrary to prostaglandin, both to maintain the homeostasis vasoconstriction. Function and platelet aggregation. TXA2biological half-life was30s, quickly transform ed into inactive thromboxane B2(TXB2). Therefore, we detect the TXB2concentration (i.e. OD) was positively correlate d with intravascular thrombosis. By comparing two groups of rats gastric perfusion, TXB2concentrations of glimepiride was significantly lower than that of the control group.Conclusion:Glimepiride can improve vascular patency rate of vascular anastomosis. Glimepiride may influence the intrinsic coagulation mechanism t o realize the prevention of thrombus formation, specific realized by which endogenous c lotting factors, further exploration and research needs as well as specific intervention m echanism.