The Comparison Of Serum Endocrine, Metabolic Status And Fat Factor Between Obese And Non-obese Adolescent Patients With Polycystic Ovary Syndrome

Objective:To compare endocrine, metabolic characteristics and fat factor between obese and non-obese adolescent patients with PCOS and observe the clinic feature of adolescents with PCOS to note any relationships between insulin resistance, leptin, adiponectin, BMI, lipid and so on.Methods:In 73 adolescent patients with PCOS, serum levels of leptin, adiponectin, glucose, lipids, sexy hormones and gonadotrophic hormone were detected. Body mass index (BMI) is measured. And oral glucose tolerance test (OGTT) is performed. Then patients were divided into obese group (BMI≥25 kg/m2) and lean group (BMI< 25 kg/m2) according to their BMI.Results:1. A significant difference in serum LH levels and LH/FSH ratios in obese PCOS girls compared to non-obese ones (17.69±12.10 vs 12.25±7.43IU/L, P＜0.05; and 3.18±1.84 vs 2.19±1.24, P＜0.01), but the level of serum DHEAS is higher in the obese patients(307.43±104.54 vs 257.12±78.73ug/dl, P＜0.05).2.The insulin and IR levels were significantly higher in obese group than that in non-obese adolescents (17.03±8.94 vs 10.69±21.38uU/mL,P<0.05 and 4.03±2.17 vs 2.43±4.81, P＜0.05).3.The level of serum TG and LDL are significantly higher in obese patients(1.67±0.86 vs 0.91±0.48 mmol/L, P＜0.01 and 2.83±0.91 vs 2.47±0.63mmol/L, P<0.05) than non-obese ones, while HDL is opposite(1.26±0.30 vs 1.63±0.32mmol/L, P<0.01). The level of serum ApoA-1 is significantly lower in obese patients(1.30±0.31 vs 1.56±0.46g/L, P<0.01),and the level of serum ApoB is significantly higher in obese group(0.91±0.27 vs 0.77±0.24 g/L, P<0.05). The level of serum ApoA-1 have a positive correlation with serum HDL in adolescent patients with PCOS (r=0.465, P=0.000), and the ApoB level have a positive correlation with LDL (r=0.831, P=0.000).4.The Leptin levels were significantly elevated in obese adolescents with PCOS compared with the non-obese ones (18242.158±7727.2082 vs 8155.6531±5188.5698 pg/ml, P＜0.01),but the level of adiponectin in obese adolescents PCOS is lower than non-obese ones (3199.233±1360.242 vs 5545.442±2928.996ng/ml, P＜0.01). Leptin levels have a positive correlation with BMI in adolescent patients with PCOS(r=0.656, P=0.000); On the other hand, adiponectin levels have a negative correlation with BMI in adolescent patients with PCOS (r=-0.417, P=0.000).Neither leptin nor adiponectin have significant correlated with insulin or glucose levels. Leptin levels also have a positive correlation with TG in adolescent patients with PCOS, and adiponectin levels have a negative correlation with TG.Conclusion:Compare to non-obese group,the obese adolescents with PCOS have more serious metabolism confusion including hyperlipidemia, impaired fasting glucose, impaired glucose tolerance,IR, higher serum leptin level and lower adiponectin levels. Leptin levels have a positive correlation with BMI in adolescent patients and the adiponectin levels are negatively associated with BMI. We must pay attention to them, and take measures to prevent the long-term complications.