Impacts Of Hydrogen Sulfide On Burn Rat Intestinal Biological Barrier Injur

Objective:To explore the impact of hydrogen sulfide (H2S) on the intestinal biologicalbarrier in severely burned rats.Methods: Randomly select104male SD rats, bodyweight220-250g, burn wererandomly divided into group (96rats) and not burn control group (8rats), in the burngroup is divided into after burns hydrogen sulfide sodium (NaHS) after theintervention group (32rats), burns propargyl glycine (PPG) after the interventiongroup (32rats), burns the control group (32rats) Thenormal group did not burn, andthe rats backs of the other three group caused30%TBSA full-thickness scald aftershaving. The cecum and intestinal con-tents of the burn groups were collected afterfeeding a week and at2d,7d,14d, and21d, after burned, biopsies were made toobserve the cecum mucosal microflora in intestinal mucus.Results contrast with the burn control group, contents of Bifidobacteria andLactobacillus in the burn group were all decreased in various phase and content ofEnterobacter, Enterococcus and Candida albicans were all increased in burn group ateach time point (each p<0.05). compared with simple burn group, quantities ofbifidobacteria and Lactobacillus in group NaHS were elevated in all time points afterinju-ry and quantities of Enterobacter, Enterococcus and Candida albicans weredecreased in burn group at each time point (each p<0.05). contrast with After burncontrol group, the contents of bifidobacteria and Lactobacillus in PPG groupdecreased significantly at each time point, while Enterobacter, Enterococcus andCandida albicans decreased (each p<0.05).Conclusion: After severe burns. Bifidobacteria and Lactobacillus were all falling.Enterobacter, Enterococcus and Candida albicans were all elevated. may acrossinsulted gut mucosal barrier to cause systemic infection. Added exogenous H2S canpromote the recovery of intestinal mucosa biological barrier function. further illustrateH2S to burn rat intestinal barrier has a protective effect. For burns after addedexogenous H2S biological protection of intestinal mucosa barrier work provides a new theoretical basis.