The Meaningful Relationship Between The Grand Total EEG Score(GTE) And Cognitive Impairment In Patients With Parkinson’s Disease

Parkinson’s disease(PD) is a common degenerative disease of central nervoussystem. Parkinson’s disease appears mostly in middle-aged and old people.Parkinson’s disease includes motor and non-motor symptoms. Among the non-motorsymptoms, cognitive impairment has a critical influence on the quality of life of thepatients and caregivers, and is a hot research topic recently.The Grand Total EEG score(GTE) reflects different types of cognitiveimpairment by evaluating abnormal changes of electroencephalogram(EEG).Objective: Investigate the meaning between the GTE score and cognitivedeficits in patients with PD.Methods: We assigned48consecutive outpatients and inpatients with PD fromthe Second Affiliated Hospital of Nanchang University between December in2012and December in2013. For everyone, age, gender, education level, motor functionscores（UPDRS、H-Y state）were recorded. The cognitive dysfunctions of PD patientswere assessed according to the the Montreal cognitive function score (MoCA), andthey were assigned into normal cognitive function group (PD-NC), mild cognitivefunction impairment group(PD-MCI), and dementia group (PD-D). All the subjectsaccepted EEG, then the GTE scale.Results:1、Significant negative correlation was found between GTE score andMoCA score in three groups of patients with PD.(Spearman rank correlation,r=-0.899, P<0.001).2、After eliminating confounding factors (gender, age, culture level, UPDRSscore), we proved that GTE score, H-Y state score both had important influence onMoCA score, and GTE score made the most impact(multiple linear regression,ρ1=-0.752, ρ2=-0.306). Further researching the subscores of GTE score, we foundthat the third one "Reactivity of the rhythmic background activity”played a key rolein MoCAscore.(multiple linear regression, ρ=-0.915). 3、Regarding the assessment of cognitive dysfunctions on patients with PD,GTE score had a general sensitivity and specificity（100%;78.1%or75%;87.5%).Conclusion: The GTE score correlates negatively with the cognitivedysfunctions (MoCA score) in patients with PD.The third subscore of GTE scoreplays the most important role in MoCA score. The GTE score is a new assessmentmethod which has some sensitivity and specificity in part. Because of the smallsample size in this study, we are unable to obtain the best diagnostic cut-off point. Itstill need further researches.