| [Objective]:Second affiliated hospital of Kunming Medical University Geriatric within three and functional neurosurgery 94 evaluation of cognitive function in hospitalized patients with Parkinson’s disease.Detection in patients with insulin resistance and other factors.Explore the presence of cognitive impairment in Parkinson’s disease patients with psychological, social and quality of life.Cognitive impairment in patients with Parkinson’s and their own analysis of the relationship between insulin resistance and related factors.And its effect on cognitive impairment in patients with Parkinson’s disease.With a view to early detection of cognitive impairment in patients with Parkinson’s disease and intervention to improve the quality of life in patients with Parkinson’s, such as providing new ideas.[Methods]:Collec Geriatric within three in our hospital between August 2013 and February 2015 Mishina and functional neurosurgery,94 cases of Parkinson’s disease patients in hospital.In selected patients,53 males,41 females, age (51-83) of average (68.34± 8.78),Course (3-20), average (11.43±6.78),This topic uses the Montreal cognitive assessment (MoCA) version scales for assessing cognitive function in patients with Parkinson’s disease using Zung’s self-rating depression scale (SDS) to evaluate depression and excluded patients with major depression,Parkinson’s disease quality of life questionnaire (PDQL) to assess the quality of life of patients with PD,Collect the patient’s height, weight, history of smoking, alcohol, pre-existing conditions (hypertension, high blood cholesterol and diabetes), level of education, duration.,Related biochemical indexes of the patients (fasting plasma glucose, insulin, total cholesterol, triglycerides) and oral glucose tolerance test (OGTT) measurement checks,HOMA method is used to calculate insulin resistance (Homa-IR), Parkinson’s disease Parkinson’s patients were divided into cognitive impairment Group (PD-MCI) and 36 non-cognitive impairment Group (PD-NCI) in 58 cases,Parkinson’s patients were divided into groups with insulin resistance (IR) and 43 cases of insulin resistance and non-group (Non-IR) and 51 cases, respectively, comparative analysis of clinical data of patients with Parkinson’s disease between the two groups, and its effects on the incidence of cognitive impairment in patients with Parkinson’s disease, and Logistic regression for other factors related to risk factors of cognitive impairment in patients with Parkinson’s disease.[Result]:1,Cognitive impairment in patients with Parkinson,26 cases of insulin resistance,72.2%, significantly higher than non-cognitive impairment Group 17, 29.3%, (P<0.05) there was a significant difference in.H-Y classification of cognitive impairment group, age of onset, MoCA scores, depression and quality of life scores were significantly higher than those without cognitive impairment group, there was a statistically significant difference (P<0.05).2,Parkinson’s group of insulin resistance and insulin resistance in non-routine situations,Between these two groups of age of onset, diabetes history, course, PDQL quality of life scores, depression score and BMI SDS MoCA scores and Homa-IR data, and the difference was statistically significant (P<0.05),61.5% incidence of cognitive impairment in insulin resistance group was higher than the non-insulin resistance group 29.6%(P<0.05), the difference was statistically significant.Severe insulin resistance group 81.5% were significantly lower incidence of cognitive impairment and severe insulin resistance group 55.2%(P<0.05), the difference was statistically significant.3,Effects of PD Logistic regression analysis of related factors of cognitive impairment, and eventually into the variable PD course, insulin-resistant IR, SDS depression score.,Three variables OR partial regression coefficients are positive and greater than 1, the three variables are all risk factors for cognitive impairment in Parkinson’s.Patients with more elderly, PD is the short duration of the patient’s risk of cognitive impairment 2.181 times;There are insulin-resistant subjects, PD 3.943 times the odds of cognitive impairment in insulin resistance in non-times;Depressed patients, PD 2.701 times times the risk of cognitive impairment in non-depressed patients.4,Effect of PD patients Logistic regression analysis of factors related to IR, ends up in a variable, high cholesterol, type 2 diabetes, BMI.Three variables OR partial regression coefficients are positive and greater than 1, and three variables are the risk factors for insulin resistance in patients with PD.PD patients suffer from Hyperlipidemia, insulin resistance is Hyperlipidemia patients 2.473 times times more likely;PD patients with type 2 diabetes, insulin resistance is in patients with type 2 diabetes in 12.745 times times more likely;Overweight patients with PD, insulin resistance is not overweight patients 4.157 times times more likely.[Conclusion]:1,Associated with insulin resistance in patients with Parkinson’s disease risk of cognitive impairment than patients with non-insulin resistance, severe insulin resistance compared with mild insulin resistance have a higher incidence of cognitive impairment.2,Insulin resistance is a risk factor for cognitive impairment in patients with Parkinson’s disease.Improve insulin resistance helps to prevent and reduce the incidence of patients with cognitive impairment.In patients with Parkinson’s disease with IR, MoCA scores, lower quality of life scores than Non-IR patients, and are more prone to depression.3,Body mass index in patients with Parkinson’s disease, age at onset, duration, degree of depression are risk factors of cognitive impairment in patients with Parkinson’s disease. Show that early detection of PD treatment, improving patient quality of life, control the development of PD, depression, losing weight, controlling blood lipids, improve insulin resistance will help to reduce the incidence of cognitive impairment in patients with PD. |
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