| Objective: To explore the roles of livin protein, an inhibitor of apoptosis protein, andvascular endothelial growth factor (VEGF) in invasion and metastasis of gastriccancer through investigating the expressions of them in gastric carcinoma (GC) andthe correlaship between these two proteins and clinical parameters,and validate theirsignificances in generation and progression of gastric carcinoma.Methods: The expressions of livin and VEGF proteins were examined byimmunohistochemistry in Sixty and six gastric carcinomas and30normal gastricmucosal samples and compared between these two groups.Results:（1）The positive rate of livin was72.73%(48/66) in tissues of gastriccarcinoma,which was significantly higher than that of13.33%(4/30) in normal gastricmucosa(p<0.05)；in gastric carcinoma，the expression of livin protein was notsignificantly related with age and sex;while was related with tumor diameter,infiltration degree, differentiation degree, lymph node metastasis and TNM staging (p＜0.05).(2)The positive rate of VEGF was65.15%(43/66) in tissues of gastriccarcinoma,which was significantly higher than the rates of20%(6/30) in normalgastric mucosa(p <0.05); the expression of VEGF was not significantly related withage, sex and differentiation degree of gastric cancer tissue, while was related withtumor diameter, infiltration degree, lymph node metastasis and clinical stage (p＜0.05).(3)There was a positive relationship between livin and VEGF proteinsexpressions in tissues of gastric carcinoma （rs=0.406, p＜0.05）.Conclusions:(1)The expression of livin in gastric carcinoma tissues was significantlyhighly than those in normal gastric mucosa.It shows that the molecularbiology factorshave changed which were correlated with degradation of livin in gastric carcinomatissues.It established the foundation for the invasion and metastasis of gastriccarcinoma.The expression of VEGF in gastric carcinoma tissues were significantlyhigher than those in normal gastric mucosa,suggesting that the occurrence of gastriccancer and VEGF protein abnormal expression is related.(2)In gastric carcinoma，the expression of livin and VEGF protein was not significantly related with age andsex.(3)The expression of livin was related with tumor diameter,differentiation degreeof gastric cancer tissue, infiltration degree, lymph node metastasis and TNMstaging.The expression of VEGF was not significantly related with degree of gastriccancer tissue, while was related with tumor diameter, infiltration degree, lymph nodemetastasis and clinical stage (p＜0.05).(4)There was a positive relationship betweenthe expressions of livin and VEGF in GC, and they may have roles cooperately in theoccurrence and development of GC. The detection of livin and VEGF expressionsmight be have certain guiding significance in the judgement of progress andmalignancy degree of gastric carcinoma. |
PDF Full Text Request