| Objective: To Analyses the incidence, mortality and survival of common cancers inZhejiang province from2005to2010, and to expire the factors which affect the lung cancerpatients survival time in order to provide theoretical basis for the prevention and control ofmalignant tumors.Methods: Data of cancer incidence registry and death registry and follow-up registry fromZhejiang were used to calculate the crude incidence(mortality), age-specificincidence(mortality), China-and World-standardized incidence (mortality), classification ofconstitution,cumulative incidence(mortality) rate, truncated incidence(mortality) rate，Annual percent change （APC） and observed and retired survival rate of common cancers bySAS9.2, Excel2010, Joinpoint3.5.4and SRUV3.01software. Using Z-test and χ2-test tocompared survival rate. Random sampling was used for500lung cancer patients who werediagnosed in2008to2009in order to explore the factors which affected those patients survivaltime. Kaplan-Meire method, Log-rank test and Cox regression model were conducted todetermine those factors.Results:1. The incidence rate was277.56/100,000in Zhejiang during2005to2010(males327.20/100,000, females226.84/100,000). The incidence rate in urban wasslightly higher than that in rural areas (278.57/100,000vs.277.06/100,000). From2005to2010, the incidence of cancer increased21.64%from242.23/100,000to294.64/100,000. Theincidence of thyroid cancer increased rapidly with a speed of26.37%per year. The top5incidence cancers were lung cancer, gastric cancer, liver cancer, colorectal cancer and breastcancer, respectively.2. The death rate was176.06/100,000in Zhejiang during2005to2010.The mortality was found significantly higher in males than in females (232.41/100,000vs.118.17/100,000), as well as in rural residents than in urban residents (177.34/100,000vs.173.63/100,000). The mortality of cancer increased4.36%from2005(170.72/100,000) to2010(178.17/100,000). The top5death cancers were lung cancer, liver cancer, gastric cancer,colorectal cancer and esophageal cancer, respectively.3. The five-year RS for5leading sitesof cancers, lung, gastric, liver, colorectal and esophageal were25.62%,39.03%,19.09%,58.73%and27.08%, respectively, in which,24.73%,38.76%,19.45%,58.85%and26.29%for males, and27.85%,39.64%,17.97%,58.57%and30.37%for females, respectively. The5-year RS in urban residents were higher significantly than in rural residents (32.03%vs. 22.29%,46.30%vs.36.32%,26.91%vs.15.72%,64.09%vs.55.16%and33.49%vs.25.23%,respectively). Female patients with breast cancer and cervix cancer had5-year RS of80.26%and55.17%.4. Cox regression model analysis shown that the factors affecting the lungcancer patients survival time were age, marital status, smoking, transfer, operation, Chinesemedicine treatment and clinical stage(stage Ⅲ and Ⅳ).Conclusions:1. The incidence of cancer increased rapidly. It was found higher in malesthan in females, as well as in urban residents than in rural residents. The main sites ofincidence were lung, gastrointestinal and breast cancer, meanwhile, the incidence of thyroidcancer increased rapidly, exploring the risk factors of thyroid cancer is in urgent need.2. Themortality of cancer increased slowly. It was found higher in males than in females, as well asin rural residents than in urban residents. The main sites of mortality were lung andgastrointestinal cancer.3. Cancer survival rates for main sites are poor, in which that of theliver is the lowest, the second is pancreatic cancer, while that of the thyroid and breast, thehighest. The survival rates of cancer patients are lower in rural areas than in urban areas.Further measures should be taken to enhance prevention and control of cancers.4. Thesurvival rate of lung cancer is poor. It may be extend to the survival time of lung cancerpatients by early diagnosis, early treatment and as far as possible operation treatment. |
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