The Relationship Between Urinary Magnesium Excretion And Subclinical Hypertensive Target Organ Damage

Objective: To investigate the relationship between the urinary magnesium excretion(24-hour urine magnesium excretion) and high blood pressure (essential hypertension) in patientswith subclinical target organ damage.Methods:64cases of clinical patients (hypertension group n=44,non-hypertensive groupn=20) to detect the24-hour urinary magnesium concentration and volume, protein-to-creatinineratio, glomerular filtration rate, left atrial diameter, interventricular septal thickness, leftventricular wall thickness, left ventricular mass index, arterial elasticity index, PWV, ABI, etc. Thegeneral information, clinical data, heart ultrasound data, urinary magnesium excretion wascompared between the two groups. According to the median of urinary magnesium excretion,hypertensive group (2.58mmol/24h) and non-hypertensive group (3.37mmol/24h) were dividedinto two subgroups. Comparative analysis the differences between the subgroups inprotein-to-creatinine ratio, GFR, arterial elasticity index, PWV, ABI,left atrial diameter,interventricular septal thickness, left ventricular wall thickness, left ventricular mass index.Results: No significant difference between the hypertension group and non-hypertensivegroup in gender, age, BMI,serum magnesium concentrations.The systolic blood pressure(134.63±18.89vs114.72±10.79mmHg, p<0.001), diastolic blood pressure(75.54±10.66vs66.00±7.97mmHg, p=0.001), mean arterial pressure(98.63±13.93vs85.39±10.15mmHg，p=0.001), Microalbuminuria(182.32±896.19vs6.80±6.39mg/L, p=0.075), The protein-to-creatini-ne ratio(157.48±587.81vs6.91±10.62mg/g, p=0.003),both sides of the PWV(right1752.63±440.33vs1414.65±178.02cm/s，p=0.001; left1800.33±460.92vs1421.80±166.33cm/s，p<0.001),septal thickness(1.05±0.21vs0.922±0.11cm, p=0.018), left ventricular wall thickness (0.93±0.19vs0.84±0.08cm, p=0.049) in hypertension group were higher than non-hypertensive group (p<0.05), The urinary magnesium excretion(2.51±1.01vs3.38±1.49mmol/24h, p=0.008),glomerular filtration rate (100.78±29.64vs120.122±45.59ml/min, p=0.046), the main arteryelasticity index (9.882±5.25vs13.028±5.77ml/mmHg×10, p=0.047) and small artery elasticityindex(3.917±2.69vs5.994±3.03ml/mmHg×100, p=0.012) was less than non-hypertensivegroup (p <0.05)..Further analysis found that urinary magnesium excretion in hypertensive group was negative correlation with the PWV(right r=-0.369,p=0.019,left r=-0.332,p=0.037), and nosignificant correlation with other hypertensive target organ damage indicators.Conclusion: Urinary magnesium excretion in hypertension patients was less than that inNon-hypertensive patients. urinary magnesium excretion was negatively correlated with bilateralPWV.