Human Papillomavirus (HPV) Infection And37Kinds Of Subtypes Distribution In Parotid Gland Tumors

Objective To study the distribution of HPV subtypes in the pariotid gland tumors,andto evaluate the relationship between HPV and pariotid gland tumors.Methods Thirty-seven HPV subtypes were detected in paraffin-embedded tissues of59cases of parotid gland tumors by flow-through hybridization and gene chip(Hybrimax),20cases of normal oral mucosa were used as controls.Results HPV-positive rates of pariotid gland tumors were57.6%(34/59), The controlgroup were all negative(0/20),The diffrence was statistically significant(Ñ…~2=20.234,P<0.05);The HPV-positive rates of benign tumor and malignent tumor of pariotid gland were59.6%(31/52) and42.9%(3/7). The HPV-positive rates of two groups was no statisticallysignificant(Ñ…~2=0.189,P>0.05);The high-risk HPV(80.7%) was the most prevalent type in thegroup of parotid gland tumors, and high-risk HPV-16/18/52were mainly prevalenttypes(61.4%); Both single-HPV and multy-HPV subtype existed in the HPV-positivesamples,and most of cases(52.9%) were infected with multy-HPV subtype.Conclusions The occurrence of parotid gland tumors may be related with HPVinfection. Both high-risk HPV and low-risk HPV subtypes were identify in parotid glandtumors, High-risk HPV subtype was the main subtype in HPV-positive group,and high-riskHPV-16/18/52were mainly prevalent types.