The Applied Study About The P300and SSR Assessment Of Cognitive And Autonomic Function In Patients With Major Depression

Objective To explore the assessment value of event-related potentials P300andsympathetic skin response(SSR) on the cognitive function and the autonomic function ofpatients with major depression.Methods The P300and SSR were detected in sixty depression patients(patient group)and sixty normal healthy people(control group) using the Dantec Keypoint.netelectromyography/evoked potential instrument, and the results were compared between twogroups, the relation of every indicators were analyzed.Results The latency of N100and N200and P300and amplitude of N200-P300inpatient group were longer and lower than those in control group respectively, there werestatistic difference between two groups (P <0.01). The latency and amplitude of the SSR inpatient group were longer and lower than those in control group respectively, there werestatistic difference between two groups(P <0.01). In patient group, the latency of SSR and thelatency of N200and P300, and the amplitude of SSR with the amplitude of N200-P300hadpositive correlation (value of r: from0.384to0.669, P <0.01). The amplitude of SSR and thelatency of N200and P300, and the latency of SSR with the latency of N200-P300hadnegative correlation (value of r: from-0.446to-0.557, P <0.01). Between P300and SSR hadcorrelation with the HAMD total score.Conclusions P300and SSR can response the severity of the cognitive function and theautonomic nervous system dysfunction in patients with major depression. P300and SSR canbe used as a secondary check of the patients with depression indicators used in clinical practice, meanwhile, can provide accurate and reliable quantitative basis for reliable clinicalvalue.