Clinical Analysis Of Non-steroidal Anti-inflammation Drugs Associated Upper Gastrointestinal Bleeding

Objectives: This research was a retrospective analysis to investigate the clinical features of non-steroidal anti-inflammation drugs associated upper gastrointestinal bleeding, which was helpful to the prevention and treatment of non-steroidal anti-inflammation drugs associated upper gastrointestinal bleeding.Methods: Clinical dates with upper gastrointestinal bleeding from 30 Jan.2009 to 30 Dec.2010 were collected from The First Affiliated Hospital Of Shantou University College. Patients were divided into two groups based on whether consumed NSAIDs 10days previous to the onset of bleeding. Age, gender, clinical characteristics, history of peptic ulcer and cardio-cerebral-vascular disease, hemoglobin level, length of stay and endoscopic characteristics were analyzed between the two groups.Results: Clinical dates of 210 patients with upper gastrointestinal bleeding were collected. 59(28.1%) patients consumed NSAIDs 10 days before bleeding. In NSAIDs group, the most frequently used NSAIDs drug was aspirin (33.9%), while lornoxicam and acetaminophen were often used, too. Patients taken NSAIDs for less than 10 days and long-term NSAIDs use, occupied 18.6%,59.3%,40.7% in NSAIDs group applied to cardio-cerebral-vascular disease, other to arthralgia caused by gout, rheumatoid arthritis etc and respiratory infection. NSAIDs group were older than control group, there were more elders(≥60 years), while control group were more yours(≤40 years)(P<0.05);NSAIDs group were more likely to have a history of cardio-cerebral-vascular disease(P<0.05), but, less likely to in a good health condition. Gastrointestinal symptoms were not distinct before bleeding in NSAIDs group (P<0.05).There were more gastric ulcer and acute gastric mucosal lesion in NSAIDs group, and also more gastric multiple ulcer than control group, antrum is the most common site for gastric ulcer(P<0.05), while there was more duodenal ulcer in control group; There was more hospital stay in NSAIDs group(P<0.05); But there were no significant differences in sex, Hemoglobin level(P>0.05).Conclusions: The patients who are the aged (over 60 years),cardio-cerebral-vascular disease are more likely to have NSAIDs associated upper gastrointestinal bleeding. Upper gastrointestinal bleeding with no gastrointestinal symptoms is the clinical characteristics of NSAIDs associated upper gastrointestinal bleeding. Gastric ulcer and acute gastric mucosal lesion are the reasons for bleeding, and the most common site for gastric ulcer is antrum. There was more hospital stay in NSAIDs group.