Antimould Effect Of Sodium Dehydroacetate And The Proper Dosage Used In Feedstuffs Of Weaned Piglets

The study was conducted to investigate the antimould effect of Sodium Dehydroacetate and the proper dosage in feed of weaned piglets. The results will provide the scientific basis for a reasonable choice on the dosage of Sodium Dehydroacetate in feed of piglets. This study included three experiments:In trial 1, the antimould effect of Sodium Dehydroacetate was investigated. There were 6 groups with 6 replicates. The feed were supplemented with 0 mg/kg (control group),50 mg/kg (group Ⅰ),100 mg/kg (group Ⅱ),150 mg/kg (group Ⅲ), 200 mg/kg (group Ⅳ),250 mg/kg (group Ⅴ) Sodium Dehydroacetate respectively. The test lasted 20 days. The result showed that:(1) The total fungi amount in each test group was lower than the control group at day 5,10,15,20. (2) The more concentration of Sodium Dehydroacetate in feed, the less total fungi amount. (3) Along with the test days increased, the total fungi amount increased at first and then decreased in the same test group.In trial 2, the effect of Sodium Dehydroacetate on growth performance, serum biochemical parameters and blood routine parameters of weaned piglets were investigated.288 crossbred (Duroc × Landrace × Yorkshire) piglets with an average body weight of (3.57±0.42) kg were randomly divided into 4 groups with 6 replicates. They were fed with basal diet (control group), basal diet supplemented with 200 mg/kg (group Ⅰ),1000 mg/kg (group Ⅱ),2000 mg/kg (group Ⅲ) Sodium Dehydroacetate respectively. The experiment lasted 42 days. The results showed that when comparing with the control group:(1) During day 10 to day 23, the ADG and ADFI in group Ⅰ、Ⅱ、Ⅲ had no significant difference (P>0.05). During day 23 to day 52, the ADFI in group Ⅰ、Ⅱ had no significant difference (P>0.05), while group Ⅲ significantly decreased 27.10%(P<.01). F/G in group Ⅲ significantly increased 11.59%(P<0.01), group Ⅰ、Ⅱ had no difference (P>0.05). (2) The blood WBC of piglets of day 52 in group Ⅰ、Ⅱ had no difference (P>0.05), but group Ⅲ significantly increased 43.46%(P<0.05). (3) The ALT in serum of piglets of day 52, group Ⅱ、Ⅲ decreased 55.94%、63.08%(P<0.01), group Ⅰ had no significant difference (P>0.05). The blood UN in group Ⅰ、Ⅱ significantly increased 59.83%、 72.48%(P<0.05), group Ⅲ significantly increased 110.50%(P<0.01). The blood CRE in group Ⅱ、Ⅲ significantly increased 36.38%、40.15%(P<0.01), group Ⅰ had no difference(P>0.05).In trial 3, the effect of Sodium Dehydroacetate on antioxidant capacity in weaned piglets were investigated.192 crossbred (Duroc × Landrace × Yorkshire) piglets of 10 days of age were randomly divided into 4 groups with 4 replicates. They were fed with basal diet (control group), basal diet supplemented with 200 mg/kg (group Ⅰ), 1000 mg/kg (group Ⅱ),2000 mg/kg (group Ⅲ) Sodium Dehydroacetate respectively. The experiment lasted 42 days. The results showed that when comparing with the control group:(1) The weight of the 51-day-old piglets in group Ⅲ significantly decreased 13.26%(P<0.05), while group Ⅰ, Ⅱ had no significant difference (P>0.05). (2) The serum T-SOD in group Ⅲ decreased significantly (P<0.01), and serum T-AOC in the group also decreased significantly (P>0.05). But the serum antioxidant indices in group Ⅰ, Ⅱ had no significant difference. (3)The liver MDA content, except the groupⅢ, group Ⅰ (P<0.01), Ⅱ(P<0.05) increased significantly. The results indicated that the diets containing 0.2% Sodium Dehydroacetate could significantly decrease the antioxidant capacity in piglets, thus there were some healthy risks by using the high level Sodium Dehydroacetate in feed.