Study On Synthesis, Structure And Properties Of Silver Complexes

In recent years, the design and synthesis of super molecular structures has been a research field of rapid expansion, which is not only because of their intriguing molecular structures, but also due to their interesting properties as new functional materials of tremendous potential applications, such as ion and molecular recognition, ion-exchange, and catalysis for reactions. These small molecules bind to DNA will beneficial in the devise of such new compounds, which can recognize specific sites of DNA. Hence, we synthesized silver complex with benzimidazol, and study their biological activity, provide reliable basis for clinical drug design.Since ancient times, silver has been as antimicrobial agent. At first, it is used to purify drinking water, wine, and vinegar. Until today, the silver salt still be used treatment of chronic skin ulcer, large area burn and prevent eye conjunctivitis of the newborn and other bacterial infections. For the past few years, many literatures reported that silver complexes have obvious antibacterial activity on staphylococcus aureus(gram-positive), escherichia coli and pseudomonas aeruginosa(gram-negative) pathogenic bacteria cell. Hence, we synthesized silver complexes, which containing V-shaped benzimidazole-based, studies on their biological activity, provide feasible basis for the design of the clinical drug.In this article, we designed and synthetized seven ligands containing V-shaped benzimidazole-based, then these ligands react with methyl acrylic acid sodium, crotonic acid sodium and silver nitrate can synthesize seven novel metal silver complexes. Moreover, the ligands and complexes were characterized by elemental analysis, IR spectra, UV-Visible spectra,fluorescence spectrum,1H NMR, molar conductivity and X-ray single crystal diffraction. These complexes composition as follow:[Ag2(Methacrylate)2(L3)2]·CH3CN(1);[Ag(Methacrylate)( L4)](2);[Ag2(Methacrylate)2(L5)]n(3);[Ag(L3)2](Crotonate)·C2H5OH·2(CH3CN)·2(H2O)(4);[Ag(Crotonate)( L4)](5);[Ag2(Crotonate)2(L5)]n(6);[Ag2(L4)2] ·(NO3)2(7);The X-ray structures of the complex show that: complex 1, 2, 5 and 7 adopted three-coordinated modes and revealed as plane triangle. The crystal structure of the complex 4 center is four-coordinated distorted tetrahedron. For complex 3 and 6, the coordination geometry around Ag(I) is best described as triangular bipyramid. The central metal Ag(I) atom bridged by two aobb ligands and two methacrylate ions to form 1-D single polymer chain structures. Due to its flexible coordination sphere of the Ag(I) atom, the spatial structure of these complexes also exhibit considerable novelty.In addition, the paper also studied the biological properties of the ligands and complexes. The interactions of the compouds with calf thymus DNA were investigated by UV–Vis spectra, fluorescent spectra, viscosity measurements. The results of the study suggest that the intercalation mode is the most likely way of the interactions of the complexes and the ligand with DNA, and the affinities for DNA are more strongly in case of complexes when compared with ligands.