Study On Mechanism Of Cell Membrane Potential Under Static Magnetic Field

With the popularity of various electrical appliances, biological effects of the magnetic field have been concern. Particularly the human nervous system is more sensitive when exposured to the magnetic field. The electric effect is a nervous system-specific effects, and neurological transmission of information through a series of electrical activity. Ion channel is the foundation of bioelectrical activity, with the generation and conduction of electrical signals. In the ion channel opening and closing process, it will cause changes in ion channel currents, which in turn cause changes in membrane potential. Most studies of the biological effects of the magnetic field were selected as the study of low frequency magnetic field conditions. Although some studies have shown that the biological effects of static magnetic field are very significant, the specific impact mechanism unknown. In the present study, select the static magnetic field as the research object.Firstly, based on the classic three-layer dielectric model cells, select 0,100,200mT static magnetic field, and use the Nernst equation to obtain the relationship between the magnetic field and the each ion channel currents.Secondly, combine the Nernst equation and Hodgkin-Huxley (HH) model to deduced the amended HH model on the magnetic field. The results show that the static magnetic field affect the conductance of ion channels and the ion channel currents change, which have an impact on action potentials. Finally, Based on H-H model, observed the changes in the action potential curve caused by transmembrane potential and Ion channels conductance value, and analyze the mechanism of action potentials. The results show that transmembrane potential and Ion channels has an impact on ascending branch and descending branch of action potential, the action potential peak, resting potential. In order to fully analyze the impact of the static magnetic field to the cell, the paper also analysis the influence of the static magnetic to the ion channel according to a two-state channel model, the study found that static magnetic fields affect the membranes through the influence of the transition probabilities of channel ions. And compare the H-H model simulation and experimental results, we found the similar results with the test.This process is use the Nernst equation to build mathematical models from the mechanics, in line with the conservation of ion diffusion, which comply with the law of conservation ion diffusion and provide theoretical support for future experimental and clinical medicine.