Self-assembly Model Of DNA Molecular Logical Operators

In recent years, with the rapid development of the computer, its computingcapability has a great development and plays an increasingly important role in thepeople’s life. However, the computer has the bottleneck of quantum mechanics and itsserial operation mode is not effective. People need new types of the computer which isfaster and more powerful. The DNA computer stands out from many theoretical modelsfor its low power consumption, high storage, high parallelism. In1994,Aldemanpractically solved a complex computational problem with DNA computing. Then theDNA computer has been a central issue of the scientific community.DNA computing has many advantages compared to traditional electroniccomputing. Although it has made great strides recently, it has in the phase of theoreticalresearch. It is so many difficults in DNA computer’s research. Logical operators as themost important operations in the electronic computing, is the cornerstone of Computing.We decided to build a logic operation model based on DNA computing, it will be abeneficial exploring for DNA computer research.Almost the existing logic operation models are in theory, it can not be done in thelaboratory. To complete logic operations in a relatively simple experimental conditions,we did not use sequencing, fluorescence which is time-consuming or difficult to build,while we use electrophoresis as a system of detection means to determine whether thereis a specific length of the molecular. We can know the results comfortably. In referenceto a number of classic models, such as sticker model, shear model. We build two logicoperation model which can be validation in the laboratory. The first logical operationmodel is based on a cyclic DNA molecule. In this model, we use the cyclic molecules tocomplete logical operations. We use specific endonuclease as the input of the logicoperation， use a cyclic DNA molecule as the logic operation of the operator，and usea specific length of the molecule exists in the final system as an output. The model issimple and practical, easy to implement. It can make logic operations in the case of theshorter, lower cost. However, due to the cyclic molecules are not easily synthesized andcalculating is not enough automation, we propose a logic operation model based on self-assembly. We utilize complementary pairing characteristics of the double-strandedmolecules with complementary gap as input specific endonuclease as computingelements, to further enhance the operability of the operation.Finally, we make a summary for characteristics and shortcomings of the model andoutlook the direction of future research.