Sex Hormone Levels On The Prognosis Of Patients With Sepsis Early Influence And Predictive Value

Objective To evaluate the effective of serum estradiol and testosterone levels and prognosis in patients with sepsis.Methods From March5,2013to August3,2013,59cases with sepsis hospitalized in Intensive Care Unit (ICU) of the affiliated hospital of medical college Qingdao University were enrolled. With72hours after enrollment, serum estradiol and testosterone levels were detected by radioimmunoassay. In addition, age, body mass index(BMI), acute physiology and chronic health evaluation II(APACHEII) score, Sepsis-related organ failure (SOFA) score, multiple organ dysfunction syndrome evaluation (MODS) score, hospital costs, hospital days were recorded. Based on28-day mortality, all the cases were divided into survival group and non-survival group.Results①Compared with non-survival group, the level of estradiol in survival group increased significantly(Z=2.107, P<0.05), while the level of testosterone decreased obviously(Z=2.437, P<0.05), APACHEII score and SOFA score lowed dramatically (t=5.917,2.712, P<0.05). There were no differences in mortality rates between the sex, age,, BMI, hospital days and hospital costs.②The results of Logistic regression analysis is that the serum of testosterone, APACHEII, SOFA is independent risk factor for sepsis patients.③The area under the receiver-operating characteristic (ROC) curve for APACHEII, SOFA,the serum of testosterone were0.89,0.77,0.71respectively. And they all could significantly predict the28-day mortality. A serum testosterone cut-point of0.64pmol/L was86%sensitive and80%specific in predicting death.Conclusion The early serum levels of estradiol and testosterone may have significant influence on the prognosis in patients with sepsis. Serum testosterone concentration is a valuable prognostic tool and potential contributor to adverse outcomes of sepsis patients.