| Background and purpose: Gastrointestinal cancer is one of the important diseases that affect human health. After surgery, the only possible way to cure, there are still a certain proportion of patients with postoperative recurrence, transfer, in the event of tumour progression and drug resistance situation for more rapid progress. This study was to survey the breakthrough point, by means of statistical investigation and analysis of traditional Chinese medicine (TCM) related to the patient’s physical distribution and the connection with the process of tumor diseases development, treatment with relatively stable TCM constitution. Aim to provide theoretical basis for prevention and treatment of gastrointestinal carcinoma of traditional Chinese medicine and clinical guidance.Objects and method: Stage Ⅲ, under the combining traditional Chinese and western medicine treatment and more than1year after gastric carcinoma patients were in this research object. After doing clinical epidemiology survey, we used SPSS20.0statistical software for frequency distribution, nonparametric test, Logistic regression analysis and other statistical analysis.Result: The general situation: By investigating85cases of gastric carcinoma patients,55cases of men, women,30cases.8patients were Under the age of40s,6patients were in40s-50s,20patients were50to60years old,29patients were in60s-70s,22patients were70s or older;22patients were gastric cancer, the number of colon cancer patients was49,14cases of patients were rectal cancer;41patients were in Gl stage,32were G2, and the number of G3was18.9cases of patients live more than five years, there are13patients’ survival time was more than3years. There were23patients received intravenous drip related Chinese medicine injection.51patients accepted the sequential therapy of traditional Chinese medicine,23patients accepted the consolidation treatment of traditional Chinese medicine. There were22patients in postoperative recurrence metastasis. Biased and clamp physical distribution: there were63cases showed physical bias (tendency). In biased or has a tendency to bias the constitution, the deficiency of46cases, Yang36cases, Yin34cases, qi depression22cases.44patients were all showed biased constitutions, including Yang deficiency and clip Yin quality(15cases), both Yang and qi deficiency (20cases), Yang deficiency and clip phlegmy wet (16cases), both Yin and qi deficiency(28cases), phlegmy wet(23cases). Physical distribution subgroup analysis:Yang deficiency, Yin deficiency, qi deficiency, phlegm wet, great quality, gentle quality, and the distribution of frequency was statistically difference in different age group. Air quality and the frequency distribution of damp and hot was different in the different gender of patients. In different survival time of patients, qi deficiency, Yang deficiency, Yin deficiency, phlegm wet of blood stasis, qi depression quality, and the distribution of frequency were difference. Patients undergoing postoperative adjuvant therapy within1year and more than1year of the patient’s physical distribution statistical were in differences. Patients with family history of Yang deficiency, phlegm wet distribution frequency were significantly higher than those without a history of genetic history who were significantly lower than the mass distribution of frequency. Sequential treatment group patients with gentle nature frequency distribution to consolidate the treatment group was significantly higher than that breaks in treatment group, Yang deficiency, Yin deficiency, qi deficiency, phlegm wet, damp and hot, blood stasis, qi depression qualitative distribution ratio was higher than the last Chinese medicine treatment group. In recurrence and metastasis group, patients’Yin deficiency, qi deficiency, phlegm wet mass, blood stasis, mass distribution frequency shift group of patients were significantly higher than without recurrence. Bias and the influence factors of distribution difference of constitution: Patients’ages, survival time, the situation of the Chinese medicine intravenous therapy might be the influence factors of overall physical fitness bias. Yang quality, and the bias of the influencing factors:level of tumor differentiation, family heredity, cycles of chemotherapy. Yin qualitative factors:gender tumor recurrence and metastasis. Deficiency of the influence factors of quality, and the biased: pathological changes, chemotherapy cycle. Phlegmy wet mass biased influence factors:pathological changes, transfer of tumor recurrence,, survival time. In addition, the sequential treatment is to avoid phlegmy wet mass biased protection factors. In the process of Chinese medicine treatment interruption treatment has no effect on the biased constitution propensity. The influence factors of tumor recurrence and metastasis: Location of tumor, tumor cells differentiation degree, Chinese medicine treatment, familial heredity. Patients with low tumor lesion location, poorly differentiated tumor cells, familial heredity, once interrupt herb treatment, had a high rate of recurrence of the tumor disease and transfered probability.Conclusion:1. Patients with stage III gastric cancer were given priority to biased constitutions, main types of biased constitutions were qi deficiency, Yang deficiency, Yin deficiency and phlegm wet.2. Location, histopathologic grading, tumor recurrence metastasis, sequential/consolidation treatment pattern, tumor family history, survival time and cycles of chemotherapy influenced stage III gastric cancer patients’traditional Chinese medicine bias constituion.3. Patients with stage III gastric cancer who had low tumor lesion location, poorly differentiated tumor pathology, family history of genetic, interruptting the dialectical treatment were easier to have tumor recurrence and metastasis. |
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