Kidney Tiaozhou IUI Treatment Combined With Small Follicle Ovulation (kidney Deficiency Syndrome) Clinical Study Of Infertility Due

ObjectiveAt present, kidney-reinforcing and menstrual cycle-regulation therapy applied to intrauterine insemination (IUI) is increasingly common, but relative research on the the clinical treatment effect and action mechanism is still deficient, especially lack of large sample test. This research based on invigorating kidney qi, is aimed to evaluate the treatment effect of yupaoyin and jianhuangyin in treating patients diagnosed with Small follicle ovulation undergoing intrauterine insemination (IUI). To observe the effect of kidney-reinforcing and menstrual cycle-regulation decoction in clinical pregnancy rate、symptoms of deficiency of kidney qi、endometrial type-thickness、blood flow and follicle blood flow, and explore the mechanism of Kidney-Reinforcing and menstrual cycle-regulation in treating Small follicle ovulationMethod168patients according with the clinical research criteria were randomly divided into two groups. They were given the same clomiphene treatment.84cases in the control group were treated with clomiphene alone, and84cases in the study group were treated with kidney-reinforcing and menstrual cycle-regulation decoction in combination with clomiphene. The syndrome points of the deficiency of kindey qi of both groups after treatment, the endometrial receptivity, follicle blood flow on the ovulation day, and clinical pregnancy rate were observed.Analyze the relevance of the syndrome points of deficiency of kindey qi and color ultrasound points of endometrium, follicle blood flow on the ovulation day. Compare the follicle blood flow and color ultrasound points of endometrium between pregnant group and non-pregnant group, and clinical pregnancy rate among different pulsatility index (PI) and resistant index (R1) of follicle blood flow on the ovulation day.ResultClinical efficacy:After treatment, the clinical pregnancy rate of the study group was15.07%,and the control group was respectively11.02%, the study group is higher than the control grope, but there is no significant difference(P>0.05). The total effective rate of the study group was71.48%, while the control group was45.24%. Both methods can lower the syndrome points of deficiency of kindey qi, and the treatment group has obvious advantage than control group (p<0.05). The symptoms of deficiency of kidney qi in the study group were significantly relieved comparing with the control group, the difference was significant (P<0.05). The color ultrasound points of endometriumon of the study group was higher than the control group on the day of HCG injection in the IUI cycle, the difference was significant (P<0.05); After treatment the comparison on pulsatility index (PI) and resistant index (RI) of follicle blood flow on the ovulation day of both groups indicated that the study group was superior to the control group (P<0.05). There were correlations between deficiency of kidney qi and endometrial color ultrasound points, pulsatility index (PI) and resistant index (RI) of follicle blood flow. Negative correlation was displayed in deficiency of kidney qi and endometrial color ultrasound points, positive correlation in deficiency of kidney qi and pulsatility index (PI) and resistant index (RI) of follicle blood flow.ConclusionKidney-reinforcing and menstrual cycle-regulation therapy combined with clomiphene has a certain curative effect in enhancing endometrial receptivity and follicle blood flow, and it can improve the symptoms of deficiency of kidney qi. Kidney-reinforcing and menstrual cycle-regulation therapy combined with clomiphene can improve the clinical pregnancy rate of patients undergoing IUI.