Efficacy Qingwenbaiduyin Modified Treatment Of Influenza

Background:Influenza (flu) is a respiratory virus prone to sexually transmitted diseases, the pathogens as influenza viruses spread mainly through droplets, influenza is a self-limiting disease, but influenza viruses can easily produce variation, and easy to spread the flu, susceptible populations widely and often produce outbreaks and epidemic hazards to human health is enormous, and therefore is regarded as one of the most threatening diseases to humans.Influenza vaccination is currently the prevention of influenza occurrence and popular one of the most effective method, but because of the flu pathogenic antigen often mutates, constantly forming new strains, therefore cannot fully control the epidemic. Commonly used antiviral drugs, antibacterial spectrum is limited, and is easy to produce drug resistance, so the application is limited. There is no recognized drug effects, safety, economy, mainly symptomatic treatment drugs clinical application.The doctor of traditional Chinese medicine called influenza:a cold, is caused by the seasonal epidemic poison the evil, belong to the category of warm disease of TCM. As early as in the classics such as"Nei Jing","Nan Jing","theory of typhoid miscellaneous diseases" has discussed about warm disease. There have been three times in the history of Chinese super-large scale of plague, the doctor of traditional Chinese medicine in the process of fighting against the disease for a long time, accumulated a wealth of experience. Qing Wen Bai Du Yin derived from the book "Yi Zhen Yi De",is the famous prescription of the ancient warm disease professional YuShiyu, Attending a variety of heat illness.Qing Wen Bai Du Yin Jia Jian Fang Is on the basis of Qing Wen Bai Du Yin remove Zhi Zi,Huang Qin,Chi Shao,Dan Pi,Zhu Ye,plus Lu Gen,Chang Pu,Yu Jin,Huo Xiang,has the effect of heat and dampness, cooling blood detoxification,achieved good effect in clinical application.Objective:This study used a randomized controlled study of methods to observe Qing Wen Bai Du Yin Jia Jian Fang decoction Recipe human influenza primary efficacy endpoint (TCM syndrome score before and after treatment,TCM syndromes efficient, PCR (influenza virus nucleic acid detection-polymeric chain enzyme reaction), cooling time,lymphocyte count) and safety indicators (Neutrophil count, hemoglobin, platelet count, Urine,liver and kidney function, enzymes), a clear effect Qing Wen Bai Du Yin Jia Jian Fang parties and subtraction security.Research methods:wangjing hospital outpatient service of60patients with influenza, treatment group30cases and control group30cases. Using simple random method, according to the order of the patient of ordinal number, specified number is odd number as the experimental group, even as the control group, were randomly divided into two groups. Treatment group take antipyretic disease and add and subtract particles,2times/day, when it is necessary to take ibuprofen sustained release capsule0.3g/time, treatment5days; Suit the dose of ibuprofen sustained release capsule0.3g/time, when necessary, treatment for five days. Recorded before and after treatment the main TCM syndrome integral, fever, cold, cough, sore throat, body aches, fatigue, etc.), PCR, antifebrile time, routine blood, liver and kidney function, myocardial enzyme, adverse events such as indicators, using SPSS18.0statistical software for statistical analysis.Results:The study included in the November2012, February2013, November2013-2014February Wang Jing Hospital Respiratory Outpatient treatment of patients met the inclusion criteria,60cases in which the test group of30patients in the control group of30patients. Difference in symptom scores before treatment (fever, chills, cough, sore throat, body aches, fatigue, etc.), body temperature, blood, liver and kidney function, enzymes and other indicators of age, gender, TCM two groups of patients had no statistics significance, comparable.Two groups of patients before and after treatment syndromes integral to compare the difference between the test group decreased symptom score higher, the difference was statistically significant; before and after treatment rate between TCM syndromes, the experimental group was significantly higher than control group, the difference was statistically significant; description Qing Wen Bai Du Yin Jia Jian Fang can improve the clinical symptoms of influenza patients. Two groups of patients were compared to normal body temperature time, the experimental group was significantly lower than the control group, the difference was statistically significant, indicating Qing Wen Bai Du Yin Jia Jian Fang has antipyretic effect.Compare the PCR of the two groups, negative rate was not statistically significant.After treatment, lymphocytes count compared with before treatment, the difference was not statistically significant.indicating no impact Qing Wen Bai Du Yin Jia Jian Fang of the above indicators.After treatment, blood (Neutrophil count, platelet count, hemoglobin content) compared with before treatment, the difference was not statistically significant. After treatment, Urine,liver function (ALT, AST), renal function (CRE, BUN), cardiac enzymes (CK-MB) were normal. During the treatment of patients without rash, drug eruption and other allergic reactions; no nausea, diarrhea and other adverse reactions. Description Qing Wen Bai Du Yin Jia Jian Fang Prescription good safety, no significant adverse reactions.Conclusions:In this study proved the Prescription of Qing Wen Bai Du Yin Jia Jian Fang can significantly relieve symptoms of influenza patients, and has a cooling effect, good safety, but for lymphocytes count, PCR and other indicators had no effect.