Syndrome Of Acute Ischemic Stroke Related Research And Carotid Atherosclerosis Graded

Objective:To investigate the relationship between the acute ischemic stroke syndromes and the grading of carotid atherosclerosis.Methods:Patients whose first diagnosis is "acute ischemic stroke" in Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine from August of2012to August of2013were included as the observed cases, record their general information, the result of carotid artery ultrasound as long as the syndrome score, Carotid artery ultrasound findings include carotid artery diameter, Intima-media thickness (IMT), If there is a plaque, what about the morphology and the location of the plaque? If there is carotid artery stenosis, what about the position and the degree of the stenosis? Then establish a database and use SPSS19.0analysis software to analyze the datas.Results:1.95cases which composed of59male and36female are included, the average age of the male is62.42+13.343while the female is68.42+10.950; The incidence of ischemic stroke rises before the age of60and declines after the age of70, the age owns the highest incidence of ischemic stroke between60to69years old; In ischemic stroke patients, the percent of men with histories of smoking and drinking are significantly higher than that of women;2.The incidence of syndromes in the acute phase of ischemic stroke from high to low are phlegm syndrome, heat syndrome, blood stasis syndrome, wind syndrome, Qi deficiency syndrome and Yin deficiency and Yang hyperactivity syndrome in turn. Phlegm syndrome often appears with heat syndrome, the second is the phlegm syndrome with blood stasis syndrome; Several syndromes usually arise at the same time in the acute phase of ischemic stroke, Whether appear lonely or with other syndromes, phlegm syndrome accounted for high proportion; The percent of the classification in carotid atherosclerosis from high to low are grade II, grade0, grade Ⅰ, grade IV, grade III, grade V;75.8%of the cases have carotid atherosclerosis plaque, of which83.3%are hard plaque, the rates of the carotid artery plaque occurrence on the right and the left are basically same;3.The grade of carotid arterial atherosclerosis in the smoking history, drinking history have no significant difference by Chi-square test (P>0.05), there is no significant difference in carotid atherosclerosis grading of hypertension, diabetes and hyperlipidemia, too(P>0.05);4.There are no significant difference in the grade of carotid arterial atherosclerosis, the incidence of stenosis and plaque in the wind syndrome, heat syndrome, phlegm syndrome, blood stasis, Qi deficiency syndrome, Yin deficiency and Yang hyperactivity syndrome (P>0.05); There is no significant difference in the grade of carotid arterial atherosclerosis and the incidence of stenosis and plaque between wind syndrome and non-wind syndrome, heat syndrome and non-heat syndrome, blood stasis syndrome and non-blood stasis syndrome, Yin deficiency and Yang hyperactivity syndrome and non-Yin deficiency and Yang hyperactivity syndrome (P>0.05); The difference in incidence of carotid artery soft plaque, mixed plaque, hard plaque have no statistically significant difference between heat syndrome and non-heat syndrome, blood stasis syndrome and non-blood stasis syndrome, Qi deficiency syndrome and non-Qi deficiency, Yin deficiency and Yang hyperactivity syndrome and non-Yin deficiency and Yang hyperactivity syndrome (P>0.05); There are no significant difference in the incidence of mixed stains, hard plaque between wind syndrome and non-wind syndrome (P>0.05); There is no significant difference in the incidence of the carotid artery soft plaque between wind syndrome and non-wind syndrome (P>0.05);5.There are statistical significance on the difference of the grade of carotid atherosclerosis between phlegm syndrome and non-phlegm syndrome, Qi deficiency syndrome and non-Qi deficiency syndrome (P<0.05); There are statistical significance on the difference of the incidence of stenosis, plaque formation and soft plaque formation between phlegm syndrome and non-phlegm syndrome (P<0.01); There are statistical significance on the difference of the incidence of soft plaque formation between wind syndrome and non-wind syndrome (P<0.05); the non parameter test, There are no significant difference in the average level of CHO, TG, HDL, LDL in the syndromes of acute ischemic stroke (P>0.05);6. NIHSS is positively correlated with the grade of carotid arterial atherosclerosis; There is no correlation between the syndromes of acute ischemic stroke and NIHSS score; There is only a only correlation between the score of the carotid atherosclerosis grading and phlegm syndrome (X3), the regression equation is Y=1.651+0.051X3.Conclution:There was a correlation between the syndromes of acute ischemic stroke and the grade of carotid arterial atherosclerosis, carotid ultrasonic examination results can be used as one of the objective evidences of diagnosis of acute ischemic stroke syndromes. This study has certainly limitations, so studies with large sample, multi centers, multi level to increase the reliability of the results are needed in the future.