Cardiac Ischemia Pharmacodynamics Thai Capsule

Objective:Through a variety of animal experiment method validation of Xintai capsule in the treatment of myocardial ischemia, at the same time through the index of examination in order to understand the pathogenesis of myocardial ischemia, For Xintai capsule of in-depth research and development and clinical application provides the experimental basis.Methods:This article take the tail intravenous injection of pituitrin (PIT) in rats induced acute myocardial ischemia, under spontaneous breathing coronary ligation in rats induced acute myocardial infarction and coronary artery ligation in dogs induced acute myocardial infarction. With three experimental animal model of canine myocardial infarction from myocardial systolic and diastolic performance and hemodynamic observations Xintai capsule on myocardial ischemia of prevention and cure function, supplemented by the rat blood rheology,hypoxia experiment in rats and the rats body torsion method, hot plate method, experiment of analgesic experiments evaluate its effectiveness.Results:(1) Xintai capsule can reduce ischemia rat’s Ⅱ lead electrocardiogram S-T segment and T wave elevation ranging; reduce serum lactate dehydrogenase (LDH) and serum creatine phosphokinase (CK) level; Narrowed the infarction range of coronary artery ligation in rats of acute myocardial ischemia.(2) Xintai capsule can significantly reduce the time point of T wave elevation range after coronary artery ligation in dogs, significantly reduced serum LDH, CK and take up of the whole heart heavy and ventricular myocardial infarction in anesthetic dogs,Significantly increased cardiac output (CO), coronary blood flow (CBF), left ventricular pressure (LVSP), reduced left ventricular pressure rise rate of the largest (+dp/dtmax), improve the anesthesia dog hemodynamics, cardiac index (SI), reduce hemodynamic end-diastolic pressure (LVEDP).(3) Xintai capsule could withstand blood stasis rats one whole blood viscosity increases, the effect of relative index is high, has an obvious role in blood circulation;can prolong the survival time of rats after pinch the trachea, have the function of the ability of hypoxia in rats; Xintai capsule has a reduced number of acetic acid in rat’s body torsion and the trend of prolong the incubation period, and can increase the rats pain caused by heat pain threshold, And have certain analgesia effect.Conelusion:Xintai capsule in anesthetic dogs and rats myocardial infarction and myocardial ischemia plays a protective role. Improve rats hemorheology indexes, enhance ability of hypoxia tolerance in rats and analgesic effect. Xintai Capsule possessed the protective effects on myocardial ischemia model.