| Purpose：The purpose of this experiment is to observation through animalexperiments Chinese medicine Yiqihuoxue compound to rats with chronic heartfailure MMP-2, TIMP-2level of expression of which reveals Chinese medicineYiqihuoxue compound on the role of MMPs/TIMPs in chronic heart failureMaterial and method：Selection of60SD rats weighing between200～230gordinary healthy male12-week-old, the use of coronary ligation with exhaustiveswimming, resulting in less food animal models of rats with chronic heart failurewere randomly divided blank group, model group, western medicine group, Chinesemedicine Yiqihuoxue Compound group, an average of rats (n=8). Six weeks aftertreatment to observe the general state of the rats, cardiac function, MMP-2,TIMP-2expression changes.Conclusion：1. Chinese medicine Yiqihuoxue compound group, the general state of westernmedicine lisinopril group rats improved markedly, increased appetite, flexibleactivities.2. Chinese medicine Yiqihuoxue Compound group to improve the efficacy of cardiacfunction is equivalent to Western medicine lisinopril group.3. Compound group of Yiqihuoxue of Chinese medicine, Western medicine groupinhibited the rat myocardial expression of MMP-2, and to promote the expressionof TIMP-2, reducing the ratio of MMP-2/TIMP-2.4.The Chinese medicine Yiqihuoxue compound, western medicine lisinopril canthrough the intervention MMP-2/TIMP-2expression, thereby inhibiting myocardialremodeling.5. The Chinese medicine Yiqihuoxue Compound group of chronic heart failure ratsMMP-2, TIMP-2level of influence in western medicine lisinopril quite. |
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