The Clinical Research On The Therapeutic Method Of Clearing The Pathogenic Heat And Promoting The Lungs Dispersive Function, Removing Phlegm And Relieving Stagnation For The Heat-phlegm Accumulation In The Lung Of Infant RSV Pneumonia

Objective:To presccribe the therapeutic method of clearing the pathogenic heat and promoting the lungs dispersive function, removing phlegm and relieving stagnation for the heat-phlegm accumulation in the lung of infant RSV pneumonia, and evaluate the clinical effect and the safety.Methods:According to the following principle: randomization, single blind and equal comparison clinical research. Some cases had been carefully chosen as study subjects according to the western medicine s diagnostic criterion of child pneumonia of RSV and the TCM diagnostic criterion of the phlegm-heat accumulation in the lung of child virus pneumonia. And base on the in-patients of Jiang Su provincial hospital of traditional Chinese medicine（2005.10～2007.2）. Trail group and contral group are divided by stratified randomization, and the ration was 1:1. The patients who are in the trial group were treated with Qingkailing injection（iv gtt） and Child Qingfei oral solution （Po）. The patients who are in the control group were treated with Ribavirin injection （iv gtt）and Compound Guaiacol Potassium Sulfonale oral solution（Po）. We compare integral changes of the cardinal symptoms and signs, secondary symptoms and signs, and curative effect. Mathematical statistics are analysed by JMTJFX 10.31 for Windows.Results:In fact, there are 31 cases of trial group and 33 cases of control group. Before the treament, there are no significant differences between the two groups general information, the cardinal symptoms and signs, secondary symptoms and signs and laboratory tests. It means that the two groups can be compared. After one course of treament, healing cases, significant effective cases, improved cases, ineffective cases and ineffective cases of two groups: the trial group were 19, 10, 2 and 0, the control group were 11, 16, 5 and 1. With the Ridit test, it showed that the effect of trial group was much better than of the control group(P_{rate of cure and excellence}＜0.05, P_{cure rate}＜0.01). Compared with the control group, the indexes of trial group of the symptoms, signs, physical examinations and laboratory tests including cough, stethocatharsis, X-ray of chest were much better. There are no significant differences between the two groups in fever, sputum, short breath, feces, vitality, sweating, thirst, nausea and vomitting, auscultation on lung, stool, blood routine test and the virus test of the secretion of nose and throat, ect. The study of clinical safety showed that Qingkailing injection and Child Qingfei oral liquid had not any harms and side effects on heart, liver, kidney and hematogenic system, ect.Conclusions:The method is effective and safe which clear the pathogenic heat and promote the lungs dispersive function, remove phlegm and relieve stagnation for the heat-phlegm accumulation in the lung of infant RSV pneumonia. The method should be widely applied in clinic.