The Clinical Efficacy And The Level Of IL-17in Peripheral Blood Of Deficiency Of Liver And Kidney Type Vilitigo Treated By Compound "Fufangbuwutangjiang"

Objective: This study is aim to investigate the changes in vitiligo lesion areas, qualityof life (DLQI),clinical symptoms of Traditional Chinese Medicine(TCM), and to detectthe level of IL-17in serum of patients before and after compound“FUFANGBUWUTANGJIANG”treatment. The efficacy of the treatment wasinvestigated from clinical symptoms and laboratory parameters. Besides, the study isaim to learn the general epidemiological characteristics of vitiligo, finding thetheoretical basis of the treatment, and exploring the relationship between IL-17andvitiligo.Methods:98vitiligo patients met the inclusion criteria were divided into treatmentgroup and control group. The treatment group were treated with compound“BUWUTANGJIANG”(which prepared by our hospital)40ml a time, twice a day. Thecontrol group was treated with glycyrrhiz in two tablets each time, and three times daily.Besides，each group was given compound “KALIZIRANDING”, a medicine of anexternal use. After a course of treatment for the two groups of patients with vitiligo,lesion area, DLQI, clinical symptom score were analyzed by statistic. The level of IL-17in serum of patients before and after treatment was detected by ELISA, and the level ofIL-17in serum of15healthy human were measured as a basis for normal value.Results:①clinical total efficiency: the treatment group is86.7%and the control groupwas63.6%, there was a significant difference in efficacy between the two groups(P<0.05).②.After a course of treatment, compared with before the treatment, lesion areascore, DLQI and TCM symptom scores have significant difference in eachgroup(P<0.05), and after the treatment, the difference between two groups is alsosignificantly(P<0.05).③The level of IL-17in serum of patients in two groups wassignificantly higher than normal people’s(P<0.01); Compared with before treatment, the level of IL-17in serum of patients decreased significantly after treatment (P<0.01),butthere was no difference between two groups(P>0.05). Compared with the control group,the level of IL-17in serum of patients in active stage and static or inactive stage patientsincreased significantly (P<0.05), and the level of IL-17in serum of patients in activestage is higher than patients in static or inactive stage patients (P<0.05).Conclusion:①T he compound “FUFANGBUWUTANGJIANG” has a good clinicalefficacy of controlling the disease, treating depigmentation, improving the quality ofpatients,life, relieving the mental stress caused by depigmentation. What is more, therewas no side effects was noticed in the study, thus the treatment should be promoted inclinical practice.②C ompared with the control group, the level of IL-17in serum ofpatients in advanced stage and stable stage increased significantly, and patients inadvanced stage is higher than patients in stable stage which indicates that IL-17mightbe involves in the occurrence and development of vitiligo and reacts the vitiligo diseasein some extent.③The level of IL-17in serum of patients decreased significantly by“FUFANGBUWUTANGJIANG”,which indicates that “FUFANGBUWUTANGJIANG”has the regulation of immune function for vitiligo patients.