Expression Of Four Cancer-testis Antigens With Its Clinical Significance In Human Brain Tumors

Objective: To investigate the expression and clinical significance ofCTCFL，OIP5，ACTL8and XAGE3in brain tumors and discuss thepossibility of these four CTA as target antigens for tumorimmunotherapy.Methods: The expression of CTCFL，OIP5，ACTL8and XAGE3mRNAwas detected in122cases of brain tumors using Reversetranscription-polymerase Chain Reaction (RT-PCR). The CTCFL，OIP5，ACTL8and XAGE3expression and the clinicopathologicalcharacteristics of tumors was analysed with SPSS16.0statistical software.Results: In122cases of brain tumors，the expression of four CTA wasXAGE3（49.18％，60/122），OIP5（13.93％，17/122），CTCFL（21.31％，26/122）ACTL8（24.59％，30/122）, respectively； In addition, twoCTA and three CTA display the phenomenon of co-expression；Statisticalanalysis showed that there was no association between clinical data andexpression frequency of these four CTAs, except for the pathological typeand expression frequency of OIP5.Conclusion: XAGE3, OIP5, CTCFL and ACTL8expressed in braintumors，in which XAGE3have higher expression frequency，suggestingXAGE3can be as a target antigen for immunotherapy of braintumor.co-expression of several CTAs provides a new insight forimmunotherapy.