| BackgroundCoronary atherosclerotic heart disease (CHD) is a worldwide leading fatal disease, seriously threat the health of human. Acute coronary syndrome (ACS) is a common clinical emergency, which is caused by acute coronary artery stenosis or occlusion due to atherosclerosis (AS) vulnerable plaques rupture and acute coronary thrombosis. ACS has the characteristics of sudden onset and high mortality, thus continue in-depth study of its pathogenesis, looking for effective intervene measures and targets has become a hot topic in the field of cardiovascular disease.With the extensive research on the pathogenesis of cardiovascular disease, the close relationship between adipokines and coronary heart disease has been gradually recognized in recent years. Adiponectin (APN) is the representative of adipokines family which has close connection with cardiovascular disease. There are a large number of studies have shown that APN is closely related to atherosclerosis and plaque stability, but its specific role remains controversial.Newly discovered adipokines Clq/TNF-related protein9(CTRP9) was the closest paralogs protein of APN, the research between CTRP9with atherosclerosis and plaque stability has not been reported, so in-depth study the relationship between CTRP9with CHD and plaque stability is important for comprehensive understanding of CTRP9, and explore new targets for the intervention of coronary heart disease and plaque stability. ObjectiveIn this study, we quantified the degree of coronary artery disease by the number of coronary artery lesions and Gensini score, measure the serum APN and CTRP9level of unstable angina pectoris (UAP) patients, acute myocardial infarction (AMI) patients, stable angina pectoris patients (SAP) and healthy controls, investigate the relationship between serum CTRP9, APN level with the severity of coronary artery stenosis and plaque stability, and their possible underlying mechanism.Methods61patients with coronary heart disease confirmed by coronary angiography were enrolled, and divided into4groups, including unstable angina pectoris (UAP) group (n=18), acute myocardial infarction (AMI) group (n=18), stable angina pectoris (SAP) group (n=25), healthy subjects without stenosis were as a control (CON) group (n=26). The serum level of CTRP9and APN were determined by enzyme-linked immunosorbent assay (ELISA). The serum level of lipids indexes and fasting glucose (FPG) were also determined. The pearson correlation analysis method was used to analyze the correlation of CTRP9and APN with the clinical basic characteristics and Gensini score.Results1. In ACS group, CTRP9level was significantly lower than those in control group (P<0.01) and SAP group (P<0.05). In AMI group, CTRP9level was significantly lower than that in SAP group (P<0.01)2.In CHD group, APN level was significantly lower than that in control group (P<0.01). In ACS group, APN level was significantly lower than that in control group (P<0.01)3. The serum CTRP9levels was positively correlated with APN (r=0.742, P<0.01) and negative correlated with FPG (r=0.592, P<0.01). CTRP9levels was only positively correlated with HDL-C levels (r=0.254, P<0.05) in CHD group. In patients of ACS, the correlation between CTRP9and FPG has enhanced (r=0.838, P<0.01), the correlation between APN and FPG, HDL has enhanced (r= 0.628, P<0.01and r=0.389, P<0.05)4. Serum CTRP9and APN levels were negatively correlated with Gensini score (r=0.579and0.777, P<0.01).ConclusionsThe serum levels of CTRP9in groups with higher plaque stability object (stable angina) was increased, and reduce the serum level of CTRP9and APN with the increase of Gensini score. CTRP9, APN were associated with ACS and the severity of coronary artery stenosis. Serum APN and CTRP9were positively correlated. Further research the specific intervention model and underlying mechanisms of APN, CTRP9in atherosclerosis and plaque stability is needed, It can provide a theoretical basis for the clinical applications of CTRP9.SignificanceWe report here the correlation between CTRP9with the severity of atherosclerosis and plaque stability, which provides a new direction for the study of arterial atherosclerosis and acute coronary syndrome, It provides a reliable theoretical and experimental basis for CTRP9as a new predictor and therapeutic target of AS vulnerable plaque, a more convenience indicator for assessing the severity of coronary artery disease, and provide a new idea and drug intervention for clinical treatment of acute coronary syndrome. |
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