Clinical Observation Of Methylprednisolone And Compound Anisodine On Acute Optic Neuritis

Objective To observe the efficacy of methylprednisolone and compoundanisodine in the treatment of optic neuritis.Methods fifty-one patient(69eyes)with optic neuritis were enrolled inthis study.There were16patients with optic never papillitis,35patients withretrobulbar neuritis.The patients were divided into treatment and controlgroup,34patients in treatment group and35patients in control group.Thetreatment group was given oral administration of vitamin B1and B12,10mg3times per day each. Systemic intravenous injection of methylprednisolone500mg melted in500ml glucose and chloride sodium injection per day for6days, then reduced to240mg for3days,then prednisolone60mg per dayorally,the dosage was reduced every week for2pills,when reduced to30mg perday,decreased progressively.Control group underwent the same therapy as thetreatment group without compound anisodine.The efficacy differences betweentwo groups were comparatively analyzed.Results Among34eyes in treatment group,9eyes were cured,13eyeswere markedly effective,11eyes were valid and1eyes was invalid. The totaleffective rate was97%.Among35eyes in in control group,6eyes were cured,8 eyes were markedly effective,16eyes were valid and5eyes were invalid.Thetotal effective rate was85.7%.The difference of total effective rate between twogroups was statistically significantConclusion The hypodermic injection of compound anisodine in treatingthe optic neuritis at its early stage has proved effectively in improving the of theoptic nerve as well as blood circulation,increasing blood flow andsupply,enhancing the restoration of tissue blood deficiency and oxygendeficiency within a short span of time,and finally heightening the visual powerof patients.