Comparative Research Of Icariin And Genistein Of Pharmacological Activity In Anti-osteoporosis

The amount of bone accumulated at the end of skeletal growth is a major determinant of osteoporosis development and fracture risk during aging. The mechanism of osteoporosis couldn’t be exact, may be related to other environmental factors including angiogenesis, immunology and neuroscience. At present, the clinical treatment for osteoporosis drugs mainly concentrated on ca lcitonin, double phosphate and hormone replacement therapy, etc., but unfortunately appeared side effects in the process of the treatment. In recent years a number of research turn to find not only low side effect but also safe and effective natural drugs to prevent osteoporosis. Genistein, a kind of soybean isoflavones, is similar to the structure of estradiol and is popular potential anti osteoporosis drug. Icariin solated from epimedium flavone glycoside, can prevent bone loss by stimulating osteoblast differentiation and inhibiting osteoclast bone resorption. The study found that icariin has more potential ability than genistein to promote osteogenesis differentiation and mineralization, because of icariin owe one isoamyl alkenyl than genistein on eight carbon. If icariin and genistein can affect the peak bone mass, clinical treatment plan will develop a new choice. It is the way that did Icariin and genistein intervene in bone mass loss through. Whether or not its mechanism is related to angiogenesis and bone immune? In view of the above hypothesis, our study is to design the quantity of the same material dose of genistein and icariin of leptospirae to affect aging rats and ovariectomized rats to compare its effectiveness. The female SD, one month old rats, six month old ovariectomized rats were administrated orally by irrigation with same molecular weight doses of epimedium glycoside and genistein for three months. The bone mineral density, femur biomechanics, serum biochemical index and bone histomorphometry were determined. In order to compare the pharmacological activity between icariin and genistein, we research the effect on peak bone mass of the rats and bone mass loss of ovariectomized rats to conclude more effective prevention and treatment of osteoporosis drugs. The ovariectomized rats associated with inflammation and vascular injury. Suppressing inflammation and stimulating angiogenesis can effectively prevent bone mass loss which resul from lack of estrogen. Compared with genistein, Icariin showed different pharmacological activity on two different physiological states of rats. Peak bone mass acquires in the puberty in growth stage. It is advantageous to the accumulation of bone mass and bone growth by promoting osteoblast differentiation and mineralization. And physiological environment of ovariectomized rats were enslaved to estrogen levels in the body. The bone mass depend on estrogen levels. Genistein, a kind of phytoestrogens, has more potential than icariin to play the role of estrogen to prevent bone loss.