| Objective:To observe the change of plasma APPL1level and FMD in patients with type2diabetes mellitus and explore the relationship of plasma APPL1and vascular endothelial function in type2diabetic patients.Methods:90patients with type2diabetes mellitus as case group,39health persons as the control group. The indexes of the participants including blood pressure, height, weight, waist circumference, hip circumference, fasting plasma glucose, fasting serum insulin, hemoglobin Alc, triglyceride, total cholesterol, high density lipoprotein, low density lipoprotein, APPL1, flow-mediated dilatation and carotid intima-media thickness were tested; the body mass index, homeostasis model assessment-insulin resistance index and waist hip ratio of the participants were calculated. APPL1was tested by ELISA, FMD was measured by high-resolution ultrasound, IMT was measured by carotid ultrasonography. The indexes of the participants in the two groups were analyzed by two independent samples t-test or t’-test; the correlation of APPL1and FMD, IMT were analyzed by Partial correlation analysis, and the correlation of APPL1and other indexes of the diabetic patients were analyzed by Pearson correlation analysis.Results:1. The levels of SBP, DBP, BMI, WHR, FPG, FINS, HbA1c, TG, TC, LDL, IMT, APPL1and HOMA-IR in type2diabetic participants were increased as compared with the health participants, P<0.01; FMD level in type2diabetic patients was reduced as compared with the health participants, P<0.01.2. APPL1had positive correlation with FPG, HbA1c, WHR and FMD in type2diabetic patients (r=0.199,0.182,0.225; P=0.031,0.017,0.039)Conclusions:The level of plasma APPL1is increased while the level of FMD is reduced in type2diabetic patients as compared with the health participants; APPL1is related to type2diabetes mellitus; maybe plasma APPL1level is not related to vascular endothelial function in type2diabetic patients, more researches should be provided. |
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