| Objective:Explore the relevant factors which affect the pregnancy rate of artificial insemination patients with polycystic ovarian syndrome to improve the pregnancy rate.Materials and Methods:Retrospective analysis482infertile women with PCOS who received AIH or AID treatment after induced ovulation in Reproductive&Genetic hospital of citic-XiangYa from January2007to December2012,699cycles in total. And study the relationship between female’s age, BMI, the rate of basic hormone LH/FSH, endometrial thickness on the day of HCG, cycles of Aiv1, numbers of AIH per cycle, forward motile spermatozoa number (a+b) in the male of AIH and age of AIH male.Result:There are482cases of women receiced699cycles of AI treatment:1. A total of172cases of women received231cycles of AIH(IUI) treatment, clinical pregnancy rate is25.1%.(1) The average age of PCOS patients in this study is28.76±3.57years old, the age span is from21to39years old.(2) The clinical pregnancy rate of who were under35years old (25.6%) is apparently higher than the patients who were older than35(16.7%),there is no statistical differences.(3) The percent of obesity is18.6%(43/231), the difference between different BMI groups is not apparently. The clinical pregnancy rate of patients who were under18.5Kg/m2,18.5～23Kg/m2,23～25Kg/m2and above25Kg/m2is23.8%,29.0%,16.3%and23.2%respectively.(4) The percent of basic hormone LH/FSH ratio more than2is2.6% (6/231), The clinical pregnancy rate of patients who’s LH/FSH ratio was under0.5,0.5～1.0,1.0～1.5,1.5～2.0and above2.0is18.6%,26%,22.9%,34.6%and16.7%respectively, the difference between different groups is not apparently.(5) The pregnancy rate is lowest when the endometrial thickness on the day of HCG is under8mm, only15.8%. The highest pregnancy rate is32.2%, when the endometrial thickness on the day of HCG is between10mm and12mm, the difference between the lowest and the highest is not apparently.The difference between all groups is not apparently either.(6) The difference of pregnancy rate between the first, the second, the third and the forth treatment is not apparently, the cumulative pregnancy rate of the forth treatment is74.7%.(7) The pregnancy rate is gradually increased along with the increased number of inseminate per cycles,which is23.1%once per cycle and27.7%twice per cycle with non-apparently difference.(8) The difference of clinical pregnancy rate between male who under35years old and older than35is not apparently.(9) The pregnancy rate is gradually increased following the increased number of forward motile sperm, which is18.2%,25%and33.3%respectively when forward motile sperm is group of under5×106/ml,5～10×106/ml and above10×106/ml,but the pregnancy rate of group of above10×106/ml is apparently higher than under5×106/ml(P<0.05).2.310cases of women received468cycles of AID treatments,and119cycles were pregnancy, the clinical pregnancy rate is25.4%.(1) The average age of PCOS patients in this study is27.91±3.38years old, the age span is from20to38years old.(2) The clinical pregnancy rate of who were under35years old (25.4%) is apparently higher than the patients who were older than35(25%),there is no statistical differences.(3) The percent of obesity is12.6%(59/468), the difference between different BMI groups is not apparently. The clinical pregnancy rate of patients who were under18.5Kg/m2,18.5～23Kg/m2,23～25Kg/m2and above25Kg/m2is22.6%,25.1%,27.2%and27.1%respectively.(4) The percent of basic hormone LH/FSH ratio more than2is0.9%(4/468), The clinical pregnancy rate of patients who’s LH/FSH ratio was under0.5,0.5～1.0,1.0～1.5,1.5～2.0and above2.0is29.4%,26.2%,24.8%,17.9%and25%respectively, the difference between different groups is not apparently.(5) No one pregnance when the endometrial thickness on the day of HCG is under8mm, when the endometrial thickness on the day of HCG is between12mm and14mm, The pregnancy rate is highes,which is32.5%. The difference between all groups is not apparently when the endometrial thickness is above8mm.(6) The difference of pregnancy rate between the first, the second, the third and the forth treatment is not apparently, the cumulative pregnancy rate of the forth treatment is67.5%.(7) The pregnancy rate is gradually increased along with the increased number of inseminate per cycles,which is12.5%once per cycle,23.9%twice per cycle and33.0%triple per cycle,with non-apparently difference.Conclusions1. Between the PCOS patients who accepted COH-AIH treatment, these following factors was not the major influencing factors, for example: female’s age, BMI, LH/FSH, the endometrial thickness on the day of HCG, treatment cycles(first four cycle), number of inseminate per cycle, male’s age and so on.But the number of forward motile sperm could apparently affect the CPR.2. Between the PCOS patients who accepted COH-AID treatment, these following factors was not the major influencing factors, for example: female’s age, BMI, LH/FSH, treatment cycles(first four cycle), number of inseminate per cycle and so on.But the endometrial thickness on the day of HCG, could apparently affect the CPR. |
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