The Significance Of PLT Count And FIB In The Diagnosis And Treatment Of Epithelial Ovarian Cancer

Ovarian cancer symptoms hidden deep in the pelvis with ovarian, even withchronic abdominal pain, bloating and other symptoms are easily overlooked.The skincancer is the most common Ovarian cancer, accounting for80%-90%of ovariancancer, early diagnosis is difficult,70%-80%of the initial visit are late today tofurther deepen the understanding of ovarian cancer, some high-risk groups receivedprophylactic oophorectomy, some tumors cytoreductive surgery patients also receivedintraperitoneal chemotherapy, ovarian cancer5-year survival rate has increased morethan50%.In recent years, more and more the Platelet and fibrinogen with ovariancancer malignant thrombocytosis is thought to be an important indicator of reactiontumor burden.Covering portions of ovarian cancer patient plasma fibrinogen alsoincreased, but the increase in platelet count and plasma fibrinogen are not consistentrelationship between clinicopathological factors and ovarian cancer, this study intendsto explore in this regard.Objective: To investigate the relationship between platelets and plasmafibrinogen with epithelial ovarian cancer patients biological behavior and prognosis.Materials and Methods1.A retrospective analysis of the Liaoning Provincial Tumor Hospital fromJanuary2009to December2010between the initial surgery for ovarian cancer patients,epithelial ovarian cancer,82patients with complete data as a research object. Thefollow-up to December2012, the follow-up time was16months-36months, including45cases of recurrence, the recurrence rate was54.88%(45/82). The same periodadmitted52patients with benign ovarian tumors as the control group (benign ovariantumor group), analysis of epithelial ovarian cancer and benign ovarian tumors inpatients with platelets and plasma fibrinogen its various clinicopathological factors andprognosis. 2.In this study, PLT>300*109/L defined as platelet increase; FIB>4g/Lincreased; blood CA125>200U/mL defined threshold exceeds this value is increased,to the peritoneal effusion≥500ml defined as ascites.3.PLT count and FIB with residual disease, histological type, ascites,histological grade, FIGO (International Federation of Gynecology and Obstetrics,International Obstetrics and Gynecology Union) surgery-pathological stage, therelationship of blood CA125compared using chi-square test; groups surgery before andafter PLT count compared using the chi-square test using SPSS17.0statistical softwarefor analysis. P <0.05was considered statistically significant.Results1.Epithelial ovarian cancer patients with no significant difference in age ofpatients with benign ovarian tumor group. Comparable between the two groups.2.Epithelial ovarian cancer in patients with platelet count and plasma fibrinogenlevels were significantly higher than benign ovarian tumor group, a statisticallysignificant difference, and the difference was significant.(Chi-square value and Pvalues were(χ~2=22.949P=0.000, χ~2=27.278P=0.000)3.Epithelial ovarian cancer group preoperative PLT count increased to43people,accounting for52.44%(43/82) the FIGO staging I+II of24patients, platelet countincreased in10cases, accounting for41.67%(10/24); Phase III+IV patients with58cases, including33cases of platelet count increased, accounting for56.90%(33/58).4.Epithelial ovarian cancer group:(1) platelet count with residual tumor,histological grade, FIGO stage, ascites comparison (chi-square values were6.502;23.953;25.972;4.174; P values were0.011;0.000;0.000;0.041are <0.05compared with the pathological type and CA125), suggesting that the above factorswas statistically significant;(chi-square values were2.949;3.115; P values were0.400;0.078), not statistically significant.(2) plasma fibrinogen with residual tumor,ascites，CA125，FIGO stage, pathological type，andpathological grade independent (chi-square value of2.105;3.405;0.814;4.586;3.238;1.359; P values were0.147;0.052;0.367;0.205;0.356;0.498>0.05), suggesting that the above factors were notstatistically significant.5.Univariate analysis PLT, and FIB recurrence (chi-square value of2.286;1.613, P values were0.131;0.204), suggesting that single factor recurrence.Logisticregression analysis of platelet count and plasma fibrinogen with epithelial ovariancancer recurrence results (P=0.230OR=0.56995%CI0.227-1.427), suggesting that the two factors in combination with recurrence.Conclusion:Epithelial ovarian cancer patients with platelet count and fibrinogen weresignificantly higher than in patients with benign ovarian tumor group; platelet countwith residual tumor, FIGO stage, pathological grade, ascites-related, which FIGOstage and pathological grade were significantly different (P=0.000); postoperativerecurrence with CA125and pathological type. Plasma fibrinogen level of CA125,residual tumor, pathological grade, ascites, FIGO stage, pathological type andrecurrence were unrelated. Epithelial ovarian cancer patients with preoperative andpostoperative platelet count difference was statistically significant, platelet count aftersurgery significantly reduced Multivariate analysis, independent of the platelet countand plasma fibrinogen with epithelial ovarian cancer recurrence.The PLT count FIBsignificance in the diagnosis and treatment of epithelial ovarian cancer.Ovarian cancersymptoms hidden deep in the pelvis with ovarian, even with chronic abdominal pain,bloating and other symptoms are easily overlooked. The skin cancer is the mostcommon Ovarian cancer, accounting for80%-90%of ovarian cancer, early diagnosisis difficult,70%-80%of the initial visit are late today to further deepen theunderstanding of ovarian cancer, some high-risk groups received prophylacticoophorectomy, some tumors cytoreductive surgery patients also receivedintraperitoneal chemotherapy, ovarian cancer5-year survival rate has increased morethan50%.In recent years, more and more the PLT and FIB with ovarian cancermalignant thrombocytosis is thought to be an important indicator of reaction tumorburden.Covering portions of ovarian cancer patient plasma fibrinogen also increased,but the increase in platelet count and plasma fibrinogen are not consistent relationshipbetween clinicopathological factors and ovarian cancer, this study intends to explore inthis regard.