| Purpose: This topic using high fat diet duplicate rat model of nonalcoholic fatty liverdisease, observed with Ganzhirong particles of nonalcoholic fatty liver disease in animalmodels of serum biochemistry,and liver tissue pathology, exploreing the relationship betweenlipid metabolism and nonalcoholic fatty liver disease.Method: Preparation of rat model of nonalcoholic fatty liver disease,the rats wererandomly divided into five group.They were polyene phosphatidylcholine capsule group,model group and particles of high, medium and low dose group. Model group was givennormal saline10ml/kg;Polyene phosphatidylcholine capsule group was given dose0.14g/kg;30%concentrations of particles of low dose0.9g/kg;70%concentrations of particlesof medium dose2.1g/kg;100%concentrations of particles of medium dose3g/kg.The rats offive groups were gastriced lavage and given high fat diet everyday. After4weeks, abdominalaorta blood were killed and draw materials for rats. Observe the morphological changes of ratliver, detection of the serum level of ALT, AST, GGT, TG, CHOL and FFA with automaticbiochemical analyzer.Result: The experimental results show:1,The results of HE staining: Polyenephosphatidylcholine capsule group and particles scattered plot low,medium and high dosegroups compared with model group, there is a significant difference（P <0.05）. High dosegroup of steatosis is minimized;2,Compared with control group, particles scattered plot in thehigh dose group of serum ALT, AST, GGT, TG, CHOL and FFA levels decreased significantly（P <0.05）.Conclusion: By improving the liver function and regulate lipid metabolism, protect theliver cells, restrain hepatocellular fatty degeneration, cure nonalcoholic fatty liver disease. |
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