Experimental Study On Curative Effect And Mechanism Of QiYin Granular Formulation On Nonalcoholic Fatty Liver Disease In Rat

Objectives: QiYin granular formulation has preferably curative effect on NAFLD, To investigate more probe into the mechanism of NAFLD and the therapeutic effects of NAFLD, accordingly, it can offer preferably theoretics and experimentation thereunder for clinic. Methods: 60 half male and half female Wistar rats were randomly divided into six groups: the control group, model control group, Essentiale control group,low-dose Qi Yin particles, the particles Qi Yin dose,high-dose Qi Yin particles,each Group 10;blank group to conventional farmers,and the remaining five were given high-fat emulsion continued feeding eight weeks,randomly selected sustained rats fed high-fat emulsion six observed liver histopathological changes,experimental set of non-alcoholic fatty liver Model modeling success addition to the standard blank group feeding and printed the same daily dose of distilled water at gavage,and the remaining five will continue to be high-fat emulsion to 15 ml / kg gavage feeding. Low, middle and high dose groups were given Qi Yin particles 3 g / kg·d-1·6g/ kg·d-1·12g/ kg·d-1·, Essentiale group to 0.069 g / kg·d-1,12 consecutive weeks after rats were killed, blood heart; fasting blood sugar (FBS), insulin(INS), Leptin(LP)were measured, immediately paunch rat liver, measure the weight of liver, calculate liver index, HE staining was observed under light microscope after liver histopathological changes.Result: The high-fat diet to reproduce the success of non-alcoholic fatty liver rat model. Qi Yin particles can decreased significantly experimental non-alcoholic fatty liver alleviate Insulin Resistance and Leptin .Conclusion: Qi Yin particles can be significantly reduced NAFLD rat liver steatosis, alleviate Insulin Resistance and Leptin.The prescription's collocation is in reason, it'is a availability prescriptionof cure NAFLD.