Study On Relationship Between TCM Syndrome And Objective Indexes Of Hypertensive Nephrosclerosis

Purpose:The incidence in recent years significantly increased due to Hypertensive nephrosclerosis by cause of end-stage renal disease (ESRD) incidence is increasing, now is still a lack of systematic study of this disease in Chinese and Western Medicine.Hypertension nephrosclerosis in patients with syndrome differentiation typing and objective indicators were observed to draw hypertension nephrosclerosis different of syndromes and objective indicators of relevance,to Provide the basis for the syndrome differentiation typing,to play a some clinical guidance role in TCM Prevention and Treatment of hypertension nephrosclerosis.Method:Use the four diagnostic syndrome to type131cases of hypertension nephrosclerosis patientst,Retrospective study, Recorded blood pressure, renal function creatinine,GFR was demonstrated in the first urea nitrogen,metabolic index (BMI, blood glucose, uric acid, triglycerides, cholesterol, HDL-C, LDL-C), urine microalbumin (mALB,β2-MG,α1-MG), echocardiography (LA, LVDD, LVDS, LVPW, EF), And analyze the Syndromes and indicators aboved related to observe differences in different syndromes objective indicators,use SPSS17.0statistical package for univariate analysis of variance, chi-square test, nonparametric rank sum test methods such as statistical analysis.Results:①among the basical types, Kidney and liver Yin Deficiency and spleen and kidney qi deficiency syndrome distribution are more,among the surface types,②Proportion of wet muddy certificate, hyperactivity, and hlegm proportion are most, every Syndrome’s objective indicators have certain differences,mALB values and (32-microglobulin value of liver and kidney yin deficiency syndrome are below the spleen and kidney qi deficiency group,mALB value of the liver yang kang is lower than phlegm,wet certificate,the wet muddy certificate, β2-microglobulin value of wet muddy card is higher than the the liver yang certificate,wet certificate.α1-microglobulin value of the wet turbid is more than phlegm, wet certificate. The CKD5of mALB and β2-MG,α1-MG values are higher than CKD1,2,3,4, CKD4period mALB value is more than CKD1period; CKD2of β2-MG values is less than CKD4period, and significantly lower than CKD3period.③The Scr value and BUN values of the liver and kidney yin deficiency are lower than the other three groups, GFR was significantly higher than the other three groups; wet muddy certificate’s Scr value,and BUN values are significantly higher than the other four groups, and GFR is significantly lower than that of other four groups.The metabolic index value for each group is basically in the normal range,the UA value of Qi and yin Deficiency, Spleen and kidney Qi deficiency and wet muddy cards is slightly higher than normal; UA values is below the Liver and kidney yin deficiency group,spleen and kidney qi deficiency, Qi and yin both deficiency group; the wet muddy’s UA value is higher than the hyperactivity of liver yang, wet certificate. CKD1’s UA value is lower than CKD4,5period.④EF, LVDD, LVDS, LVPW values of each group are within the normal range, and LA values are higher than normal.Liver and kidney yin deficiency syndrome’s LA value,LVDD values,LVDS value are below the spleen and kidney qi deficiency; the wet muddy’s LA value is higher than the hyperactivity of liver yang, phlegm, liver yang’s LVPW value is significantly higher than the phlegm.Conclusions:①Evolution of the pathogenesis of hypertensive renal damage has a certain regularity, this card early mainly in liver and kidney yin deficiency,advanced mainly in spleen and kidney qi deficiency,in marked cards,early and mid-yang,sputum the dampness is the main with advanced to wet muddy certificate-based,simple stasis below normal.②Urining microalbumin can be used as hypertension early indicators of kidney damage, and with the progression of the amount of protein gradually increase the severity of kidney damage,a gradual decline in renal function.③Glucose, blood lipids are in normal range,not prompt Renal function progression,Uric acid in hypertensive renal damage late significantly elevated is a risk factors for progression of renal,④hypertensive nephrosclerosis has heart damage, and left atrial enlargement is the first performance.However,with the increase in the degree of renal impairment, LA value, LVDD value, LVDS value increased significantly.Prompting with the progression of kidney damage increase, eventually causing left ventricular hypertrophy,and heart increases.⑤In this study sample size is relatively small, distribution of syndrome is uniform, The results derived syndromes associated with objective indicators relatively limited,so it needs further expand the sample size.