The Expression And Significance Of Ki67, P53and CyclinD1in Primary Small Bowel Malignant Tumors

Objective：To investigate the expression and Significance of Ki-67, P53andCyclinD1in primary small bowel malignant tumors (adenocarcinoma of smallintestine, small intestinal stromal tumors and small intestinal lymphoma)Methods: The distribution of Ki-67, P53and CyclinD1in84casesadenocarcinoma of small intestine,30cases small intestinal stromal tumors,15casessmall intestinal lymphoma and10specimens of normal small intestinal tissues weredetected by immunohistochemical technique.Results：1.The positive expression rate of Ki-67compared with normal small intestinetissues in adenocarcinoma of small intestine, small intestinal stromal tumors, smallintestinal lymphoma are57.14%,46.67%and73.33%, the positive expression rate ofP53are42.86%,50%and53.33%, the positive expression rate of CyclinD1are44.05%,30%and33.3%.2. The expression of Ki-67, P53and CyclinD1were positively related to thegrade of the primary small bowel malignant tumors.3. In the small intestine adenocarcinoma, small intestinal stromal tumors, smallintestinal lymphoma groups, there were no significant difference in gender, age of theexpression of Ki-67, P53and CyclinD1(P>0.05).In the small intestineadenocarcinoma groups, there were significant difference between the lowdifferentiation and high differentiation groups (P<0.05), there were significantdifference between the medium differentiation and high differentiation groups(P<0.05), but there were no significant difference between the low differentiation andmedium differentiation group(sP>0.05). In the small intestinal stromal tumor groups,there were significant difference between the high risk groups and the low risk groups(P<0.05), there were significant difference between the moderate risk groups and thelow risk groups (P<0.05), but there were no significant difference between the highrisk groups and moderate risk groups(P>0.05). In the small intestinal lymphoma groups, there were significant difference between the I+II period and the III+IVperiod (P<0.05)(according to the stage of Ann Arbor).4. In the adenocarcinoma of small intestine groups, there were positivecorrelation between P53and Ki-67(P<0.05), there were positive correlationbetween P53and CyclinD1(P<0.05), there were positive correlation between Ki-67and CyclinD1(P<0.05). In the small intestinal stromal tumor groups, there werepositive correlation between P53and Ki-67(P<0.05), there were no correlationbetween P53and CyclinD1(P>0.05), there were positive correlation between Ki-67and CyclinD1(P<0.05). In the small intestinal lymphoma groups,，there were positivecorrelation between P53and Ki-67(P<0.05)，there were no correlation between P53and CyclinD1(P>0.05), there were no correlation between Ki-67and CyclinD1(P>0.05).Conclusion: Ki-67, P53and CyclinD1may play an important and positive rolein the malignant degree judgment, progress and prognosis diagnosis of the primarysmall bowel tumors.