| Objective: To investigate the histological mechanism of micro-plasma-radiofrequency(MPR) with different treatment parameters through experimentalstudy, so as to provide reference for treatment regimen choices in clinical application.Methods: Two white pigs, aged5-6months, were used and received MPRtreatment on pig dorsal skin. In each pig,12different parameters (including energy,duration time, repeat times, sliding speed) were adopted to perform treatment on12treatment zones on the dorsum. Immediately after treatment,7days,1,3,6monthsafter treatment, we observed the healing process and took specimens from eachtreatment zone. HE staining and Masson trichrome staining were performed to assessthe width and depth of tissue injury and heat effect, the healing process andneocollagenesis. Heat shock protein(HSP) was also detected by immunohistoche-mistry..Results: According to the healing process, the roller tip produces fractionaltreatment, which is similar to fractional laser treatment. The roller tip can be used forentire treatment zone with rapid healing and low risk. The treatment of stationary tipwith no sleeve is not fractional, but covers all the treatment area. It can be sued tostrengthen the treatment at local area. The stationary tip with sleeve has a good heateffect, with some irregular fractional injury and rapid healing process. The tissueresponse is not stable depending on the management of doctors.Conclusion: The MPR is a promising fractional skin resurfacing technique. Thesuperficial ablative treatment by plasma and the following heat effect byradiofrequency cause the skin resurfacing, neocollagenesis and remodeling. It can beused for scar treatment and skin tightening. Appropriate treatment regimen should bechosen to guarantee the therapeutic effect and safety. |
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