The Correlation Of Plasma Homocysteine, Abnormal Glucose Tolerance And Coronary Artery Lesions

Objective:To explore the impact of the abnormal glucose metabolism、 plasmahomocysteine on coronary artery diseases by analysing the2hours postprandial bloodglucose、plasma homocysteine of coronary heart disease patients.Methods:collected the clinical medical records of the367patients who were supectd ofgeting coronary artery disease in Cardiovascular Division of our hospital from2009to2012. Clinical medical records include: general condition of patients: name, gender,age, weight, height, family history, and alcohol consumption, smoking, previousdiseases, drug use and Liver and kidney function, fasting blood glucose, blood lipids,fasting insulin levels, homocysteine,2h postprandial blood glucose and coronaryangiography results.the patients were divided into coronary heart disease group andnon-CAD group According to the coronary angiography results. According to the2-hour postprandial blood glucose levels,we devide the patients diagnosised ofcoronary heart disease into: normal glucose tolerance group (CHD-NGT group),impaired glucose tolerance group (CHD-IGT group), three groups of diabetic group(CHD-DM group). Clinical datas between the groups, the results of coronaryangiography were analyzed by statistical methods.Results:The serum hcy levels of CHD-IGTgroups and CHD-IGT groups weresignficantly higher than those of the normal controls group(p＜0.01, p＜0.01),alsohigher than CHD-NGT groups(p＜0.01).CHD-NGTgroups also signficantly higherthan the normal controls group(p＜0.05),but there was not difference between theserum hcy levels of CHD-IGT groups and CHD-NGT groups (P＞0.05). CHD-IGTgroups’ and CHD-DM groups’ two or three coronary artery lesions were signficantlyhigher than CHD-NGT groups’(p＜0.01);and CHD-NGTgroups’one coronary arterylesion higher than CHD-DM groups’ and CHD-IGT groups’(p＜0.05). Degree of coronary artery stenosis: Severe stenosis rates of CHD-DM groups and CHD-IGTgroups were higher than the severe stenosis rates of CHD-NGT groups (p＜0.05) Thecoronary artery lesion of CHD-NGT groups were mild more narrowly degree thanDM group and IGT group, a significant difference (P <0.05),and with elevated bloodsugar Gensini total credit also increased (P <0.05).whether or not combined theglucose intolerance,patientswas the more plasma homocysteine level the morenumber of coronary artery lesions.The patients’plasma homocysteine level of thethree coronary artery lesions groups higher than that of two or one coronary arterylesions groups (P <0.05), statistically significant.Rather than the patients’plasmahomocysteine level of the two coronary artery lesions groups generally higher thanthat of one coronary artery lesions groups，and the difference between the two groupswere statistically significant(p <0.05). Related to coronary heart disease risk factorsused logistic multiple regression analysis. Exclude confounding factors such as bloodpressure, age, gender, we found:2-hour Plasma Glucose, lnHCY, LDL-C wereindependent risk factors for coronary heart disease, which was the2-hour PlasmaGlucose the most obvious.Conclusions:1、 Elevated plasma homocysteine, impaired glucose tolerance is a risk factor incoronary artery disease.2、 Plasma homocysteine levels and impaired glucose tolerance in patients withcoronary artery lesions positively correlated.